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Beyond the limitations of conventional treatments including endoscopic balloon dilatation and the application of oral\/topical corticosteroids, several cell therapies have been recently attempted. However, such methods are still limited in clinical situations and existing setups, and the efficacies are less in some cases since the transplanted cells hardly remain at the resection site for a long time due to swallowing and peristalsis of the esophagus. Thus, a cell transplantation platform directly applicable with clinically established equipment and enabling stable retention of transplanted cells can be a promising therapeutic option for better clinical outcomes. Inspired by ascidians that rapidly self\u2010regenerate, this study demonstrates endoscopically injectable and self\u2010crosslinkable hyaluronate that allows both endoscopic injection in a liquid state and self\u2010crosslinking as an in situ\u2010forming scaffold for stem cell therapy. The pre\u2010gel solution may compatibly be applied with endoscopic tubes and needles of small diameters, based on the improved injectability compared to the previously reported endoscopically injectable hydrogel system. The hydrogel can be formed via self\u2010crosslinking under in vivo oxidative environment, while also exhibiting superior biocompatibility. Finally, the mixture containing adipose\u2010derived stem cells and the hydrogel can significantly alleviate esophageal stricture after endoscopic submucosal dissection (75% of circumference, 5\u2009cm in length) in a porcine model through paracrine effects of the stem cell in the hydrogel, which modulate regenerative processes. The stricture rates on Day 21 were 79.5%\u2009\u00b1\u20092.0%, 62.8%\u2009\u00b1\u20091.7%, and 37.9%\u2009\u00b1\u20092.9% in the control, stem cell only, and stem cell\u2010hydrogel groups, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Therefore, this endoscopically injectable hydrogel\u2010based therapeutic cell delivery system can serve as a promising platform for cell therapies in various clinically relevant situations.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10521","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:53:07Z","timestamp":1681869187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Endoscopically injectable and self\u2010crosslinkable hydrogel\u2010mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5159-357X","authenticated-orcid":false,"given":"Hyunsoo","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Republic 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