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Several agents have been developed to prevent adhesion formation, such as barriers, anti\u2010inflammatory and fibrinolytic agents. The Food and Drug Administration (FDA) has approved the use of physical barrier agents, but they have been associated with conflicting clinical studies and controversy in the clinical utilization of anti\u2010adhesion barriers. In this review, we summarize the human anatomy of the peritoneum, the pathophysiology of adhesion formation, the current prevention agents, as well as the current research progress on adhesion prevention. The early cellular events starting with injured mesothelial cells and incorporating macrophage response have recently been found to be associated with adhesion formation. This may provide the key component for developing future adhesion prevention methods. The current use of physical barriers to separate tissues, such as Seprafilm\u00ae, composed of hyaluronic acid and carboxymethylcellulose, can only reduce the risk of adhesion formation at the end stage. Other anti\u2010inflammatory or fibrinolytic agents for preventing adhesions have only been studied within the context of current research models, which is limited by the lack of in\u2010vitro model systems as well as in\u2010depth study of in\u2010vivo models to evaluate the efficiency of anti\u2010adhesion agents. In addition, we explore emerging therapies, such as gene therapy and stem cell\u2010based approaches, that may offer new strategies for preventing adhesion formation. In conclusion, anti\u2010adhesion agents represent a promising approach for reducing the burden of adhesion\u2010related complications in surgical patients. Further research is needed to optimize their use and develop new therapies for this challenging clinical problem.<\/jats:p>","DOI":"10.1002\/btm2.10565","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T01:42:48Z","timestamp":1687830168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Techniques for navigating\n                    <scp>postsurgical<\/scp>\n                    adhesions: Insights into mechanisms and future directions"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5935-6083","authenticated-orcid":false,"given":"Jiahui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Textile Engineering, Chemistry and Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Textile Engineering, Chemistry and Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Textile Engineering, Chemistry and Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-3401","authenticated-orcid":false,"given":"Arielle","family":"Perez","sequence":"additional","affiliation":[{"name":"UNC School of Medicine Department of Surgery University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Yao","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center Department of Obstetrics &amp; 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