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In this study, we investigated this relationship using in vitro and in vivo models. Clinical observations revealed distinct morphological changes and increased vascularity at pathological scar sites. Further analysis using OCTA, immunohistochemistry, and immunofluorescence confirmed the involvement of angiogenesis in scar formation. Our indirect co\u2010culture systems demonstrated that endothelial cells enhance the proliferation and migration of fibroblasts through the secretion of cytokines including VEGF, PDGF, bFGF, and TGF\u2010\u03b2. Additionally, a suspended co\u2010culture multicellular spheroid model revealed molecular\u2010level changes associated with extracellular matrix remodeling, cellular behaviors, inflammatory response, and pro\u2010angiogenic activity. Furthermore, KEGG pathway analysis identified the involvement of TGF\u2010\u03b2, IL\u201017, Wnt, Notch, PI3K\u2010Akt, and MAPK pathways in regulating fibroblasts activity. 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