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However, the current mainstream local medications primarily rely on intra\u2010pocket administration, which, while avoiding the side effects of traditional systemic drugs, presents challenges such as inconvenience, discomfort, and the need for professional assistance, thus affecting patient compliance. Herein, we introduce a minocycline\u2010loaded dissolvable microneedle (Mino\u2010DMN) patch that allows for local and efficient delivery of minocycline to gingiva for the treatment of periodontitis. A two\u2010step casting micro\u2010molding process involving vacuum drying and freeze drying is employed to concentrate minocycline in the microneedle part and limit its diffusion into the patch backing. The resulting Mino\u2010DMN patch features an array of minocycline\u2010enriched gelatin MNs with a porous HA patch backing. The microneedles can penetrate into gingiva with enough mechanical strength and quickly release minocycline into the gingival tissue, ensuring prolonged local residence of the drug and minimizing its loss to saliva. In vivo experiments show Mino\u2010DMN inhibits pro\u2010inflammatory factors, promotes anti\u2010inflammatory factors, and stimulates bone formation, surpassing topical application and comparable to the inconvenient and discomfort administration of Periocline\u00ae. This proposed Mino\u2010DMN offers a simple, efficient, user\u2010friendly strategy for the adjunctive treatment of periodontal disease.<\/jats:p>","DOI":"10.1002\/btm2.10730","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:26:39Z","timestamp":1729477599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Huimin","family":"Li","sequence":"first","affiliation":[{"name":"School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Stomatology Hospital  Hangzhou Zhejiang 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