{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:12Z","timestamp":1772118312413,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI166120"],"award-info":[{"award-number":["R21AI166120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM128648"],"award-info":[{"award-number":["R35GM128648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001906","name":"Washington Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001082","name":"Camille and Henry Dreyfus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp;amp; Transla Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>State the Purpose<\/jats:title>\n                    <jats:p>\n                      Obtaining high\u2010quality samples to diagnose streptococcal pharyngitis in pediatric patients is challenging due to discomfort associated with traditional pharyngeal swabs. This may cause reluctance to go to the clinic, inaccurate diagnosis, or inappropriate treatment for children with sore throats. Here, we determined the efficacy of CandyCollect, a lollipop\u2010inspired open\u2010microfluidic pathogen collection device, to capture Group A\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      (GAS) and compare user preference for CandyCollect, conventional pharyngeal swabs, or mouth swabs in children with pharyngitis and their caregivers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All child participants (30\/30) were positive for GAS by qPCR on both the mouth swab and CandyCollect. Caregivers ranked CandyCollect as a good sampling method overall (27\/30), and all caregivers (30\/30) would recommend CandyCollect for children 5\u2009years and older. Twenty\u2010three of 30 children \u201creally like\u201d the taste and 24\/30 would prefer to use CandyCollect if a future test were needed. All caregivers (30\/30) and most children (28\/30) would be willing to use CandyCollect at home.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All participants tested positive for GAS on all three collection methods (pharyngeal swab, mouth swab, and CandyCollect). While both caregivers and children like CandyCollect, some caregivers would prefer a shorter collection time. Future work includes additional studies with larger cohorts presenting with pharyngitis of unknown etiology and shortening collection time while maintaining the attractive form of the device.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/btm2.70001","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:44:52Z","timestamp":1741070692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Capture of Group A\n                    <i>Streptococcus<\/i>\n                    by open\u2010microfluidic CandyCollect device in pediatric patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-7799","authenticated-orcid":false,"given":"Wan\u2010chen","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4217-4777","authenticated-orcid":false,"given":"Ingrid H.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria A. M.","family":"Shinkawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Hatchett","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9406-6767","authenticated-orcid":false,"given":"Juan C.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-5879","authenticated-orcid":false,"given":"Anika M.","family":"McManamen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-2327","authenticated-orcid":false,"given":"Xiaojing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-9034","authenticated-orcid":false,"given":"Erwin","family":"Berthier","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-2080","authenticated-orcid":false,"given":"Sanitta","family":"Thongpang","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-8532","authenticated-orcid":false,"given":"Ellen R.","family":"Wald","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-8292","authenticated-orcid":false,"given":"Gregory P.","family":"DeMuri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-1435","authenticated-orcid":false,"given":"Ashleigh B.","family":"Theberge","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Washington  Seattle Washington USA"},{"name":"Department of Urology School of Medicine, University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00101\u201013"},{"key":"e_1_2_11_3_1","unstructured":"Centers for Disease Control and PreventionUpdated June 27 2022. 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