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Throughout disease progression, such as in cancers, bone defects, and cardiac conditions, the mechanical microenvironment of tissues can undergo dramatic changes, exerting profound effects on disease development. Adipose tissues are inherently mechanosensitive and mechanoresponsive, continually exposed to various mechanical stresses in daily life. The hypertrophy and accumulation of adipocytes can lead to obesity, a condition strongly associated with numerous health risks, like diabetes and cancers. In this review, we aim to elucidate the reciprocal mechanical interaction between adipose tissues and disease progression, encompassing cancers, bone defects, and cardiac pathologies. The existing literature suggests that alterations in the mechanical microenvironment during disease advancement may impede adipogenic differentiation, induce adipocyte dedifferentiation, and escalate the secretion of inflammatory cytokines. Conversely, dysregulation of adipose tissues can result in the deposition of extracellular matrix components, stiffening the microenvironment and fostering disease progression in a cyclical fashion. Therefore, in future treatments of related diseases, a combined approach integrating mechanotherapeutics and obesity management holds promise for achieving the desired enhanced therapeutic outcomes.<\/jats:p>","DOI":"10.1002\/btm2.70065","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T06:40:46Z","timestamp":1759473646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanical interplay between adipose tissues and disease progression"],"prefix":"10.1002","volume":"11","author":[{"given":"Hangyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hand and Microsurgery, People's Hospital of Zhenhai District (Ningbo No.7 Hospital), Ningbo, Zhejiang 315202, China"},{"name":"Department of Plastic Surgery The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Health Science Center Ningbo University  Ningbo Zhejiang 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