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Hemodynamic changes during embolization were simulated by modeling the terminal resistance vessels as a porous medium. An in vitro experimental platform has been developed to replicate the embolization process. Based on these simulations and experimental data, a quantitative method was established to evaluate the embolization endpoint using local arterial blood pressure. The method was further validated through renal artery embolization experiments in pigs. The quantitative method effectively predicted changes in local arterial pressure and flow rate, with an average error of approximately 1.65% in simulations and 3.09% in in vitro experiments. In animal studies, the pressure\u2010based endpoint evaluation method closely aligned with imaging results, reducing the required embolic agent by an average of 17.86%. 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