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However, clinical trials have shown limited therapeutic effectiveness, largely because of low efficiency in penetrating the inflamed colon and their inconsistent in vivo immunomodulatory ability. In this study, we generated genetically engineered adipose\u2010derived human MSCs constitutively expressing CXC chemokine receptor 4 and interleukin 10 (CXCR4\u2010IL10\u2010MSCs) to promote their delivery to the inflamed colon and enhance their immunosuppressive capability. Compared to unmodified MSCs, CXCR4\u2010IL10\u2010MSCs exhibited enhanced trafficking to the inflamed colon and achieved improved therapeutic effects in dextran sulfate sodium (DSS)\u2010challenged colitic mice. Upon a chronic DSS re\u2010challenge, CXCR4\u2010IL10\u2010MSCs showed enhanced long\u2010term protective effects. These findings demonstrate that stable ectopic expression of CXCR4 and IL10 enhances the therapeutic efficacy of MSCs and supports the development of an optimized MSC\u2010based product capable of inducing an improved long\u2010term protective immune memory in IBD.<\/jats:p>","DOI":"10.1002\/btm2.70083","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T17:41:04Z","timestamp":1765906864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved efficacy and long\u2010term protective effects of\n                    <scp>CXCR4<\/scp>\n                    \/\n                    <scp>IL10<\/scp>\n                    bioengineered mesenchymal stromal cells in a model of inflammatory bowel 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