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This review explains how non\u2010invasive physical stimulation (NIPS) reprograms TAMs via defined couplings between physical inputs and signaling pathways. Hypoxia\u2010tolerant photodynamic strategies and mild photothermal heating reset hypoxia\u2010 and lactate\u2010driven programs; cavitation\u2010dominant ultrasound and sonodynamic therapy trigger danger signaling and reactive oxygen species; ultrasound microbubble destruction provides endothelial repair cues; nanosecond pulsed electric fields activate cyclic GMP\u2010AMP synthase\u2013stimulator of interferon genes (cGAS\u2013STING) pathway; piezoelectric materials convert mechanical input into calcium\u2010dependent transcription; and appropriately dosed radiotherapy elicits immune\u2010active responses while avoiding hypoxia\u2010driven M2 recruitment. Across models, these regimens promote pro\u2010inflammatory reprogramming, normalize aberrant vasculature, and strengthen antitumor immunity while restraining immunosuppression. We synthesize parameter windows, delivery options, and combination strategies with checkpoint blockade and macrophage\u2010directed agents to guide the translation of NIPS into precise, low\u2010toxicity TAM\u2010targeted immunotherapy.<\/jats:p>","DOI":"10.1002\/btm2.70126","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:24:06Z","timestamp":1772983446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering the tumor immune landscape: Translating non\u2010invasive physical stimulation into tumor\u2010associated macrophage\u2010targeted cancer immunotherapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4272-4080","authenticated-orcid":false,"given":"Tingyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Department of Medical Imaging, The Affiliated Changsha Central Hospital, Hengyang 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