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Herein, a reactive oxygen species (ROS) responsive robust hydrogel (THMA\/TCMC\u2010Gel@Cur) based on \u201cthiol\u2010ene\u201d click chemistry was developed for infected wounds. The addition of curcumin\u2010loaded gelatin nanoparticles (Gel@Cur) imparted excellent antibacterial and antioxidant properties to the THMA\/TCMC\u2010Gel@Cur hydrogel. Thiols and alkenes quickly formed thioether bonds through the \u201cthiol\u2010ene\u201d click chemical reaction. The hydrophobic thioether bonds could be oxidized to hydrophilic sulfoxide bonds by ROS. THMA\/TCMC\u2010Gel@Cur hydrogel formed by \u201cthiol\u2010ene\u201d click chemistry could respond to ROS and increase water molecules to enter the interior of the hydrogel by switching the hydrophilic to hydrophobic characteristics, thereby accelerating drug diffusion in the porous network. In vivo results showed that wounds treated with THMA\/TCMC\u2010Gel@Cur hydrogel had a wound closure ratio of 93.56% within 14\u2009days, which was significantly higher than the other treatment groups. The THMA\/TCMC\u2010Gel@Cur hydrogel exhibited significant potential for clinical application, poised to enhance the quality of life for patients suffering from infectious dermatological disorders.<\/jats:p>","DOI":"10.1002\/btm2.70143","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:42:32Z","timestamp":1775713352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ROS<\/scp>\n                    \u2010responsive robust hydrogels based on thiol\u2010ene click chemistry for enhancing the healing of infected wounds"],"prefix":"10.1002","volume":"11","author":[{"given":"Huaping","family":"Li","sequence":"first","affiliation":[{"name":"Guangzhou Dermatology Hospital. 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