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In this study, we developed a novel therapeutic strategy based on myeloid ecotropic viral integration site 1\u2010engineered exosomes loaded with curcumin (Meis1\u2010Exo@Cur). This nanotherapeutic platform exhibited potent protective effects in both cellular and animal models of P\u2010ALI, significantly reducing inflammation, oxidative stress, and apoptosis while promoting tissue repair. Mechanistically, Meis1\u2010Exo@Cur exerted its therapeutic effects through coordinated inhibition of the nuclear factor kappa\u2010B\/mitogen\u2010activated protein kinase signaling pathways and activation of the Nrf2\/HO\u20101 pathway, accompanied by remodeling of the immune microenvironment. 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