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This study aims to develop and optimize endovascular magnetic filtration devices to enhance IAC efficacy, by targeted removal of excess drug\u2010coated ultrasmall superparamagnetic iron oxide (USPIO) particles from circulation. Device performance was evaluated through multi\u2010physics simulations that coupled the transport of drug\u2010coated magnetic particles in blood flow with magnetic interactions and magnetophoretic forces. A dimensional analysis framework was applied to characterize particle capture efficiency () across alternative device designs, and numerical predictions were compared with published benchtop experiments. Optimized multi\u2010stage filters achieved up to ~80% predicted capture efficiency, while reducing the risk of intravascular device collapse. 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