{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:07:23Z","timestamp":1790064443012,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0121"],"award-info":[{"award-number":["CMRPG3N0121"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0122"],"award-info":[{"award-number":["CMRPG3N0122"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRPB03"],"award-info":[{"award-number":["BMRPB03"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102314\u2010B\u2010182\u2010016"],"award-info":[{"award-number":["112\u20102314\u2010B\u2010182\u2010016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102314\u2010B\u2010182\u2010023\u2010MY3"],"award-info":[{"award-number":["113\u20102314\u2010B\u2010182\u2010023\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114\u20102811\u2010B\u2010182\u2010045"],"award-info":[{"award-number":["114\u20102811\u2010B\u2010182\u2010045"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp; Transla Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cartilage tissue engineering remains challenged by uncontrolled scaffold\u2013host interactions after implantation, particularly host tissue infiltration that can disrupt cartilage formation and compromise scaffold integrity. Although biomaterial\u2010based encapsulation strategies have been developed to reduce host interference, excessive restriction of scaffold\u2013host interface may also limit the exchange of nutrients, oxygen, and metabolic wastes. Therefore, an effective encapsulation strategy must protect the developing tissue from excessive host infiltration while maintaining a permissive environment for tissue formation. Here, we engineered a fibroblast\u2010based cell sheet to regulate scaffold\u2013host interactions in a nude mice implantation model. Fibroblast cell sheet wrapping protected the scaffold by limiting host cellular infiltration, but cartilage extracellular matrix (ECM) formation was also reduced within the scaffold. Notably, EPC incorporation into the cell sheet restored cartilage ECM deposition and enhanced peri\u2010scaffold vascularization. These results demonstrate that cell sheet\u2010based encapsulation can provide not only a protective function against excessive host infiltration but also a bioactive interface that regulates scaffold\u2013host interactions, with EPC incorporation promoting peri\u2010scaffold vascularization and supporting cartilage matrix formation within the scaffold.<\/jats:p>","DOI":"10.1002\/btm2.70177","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:26:36Z","timestamp":1790061996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A bioactive cell sheet interface regulates scaffold\u2013host interactions for cartilage regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-1817","authenticated-orcid":false,"given":"Yi Chieh","family":"Chang","sequence":"first","affiliation":[{"name":"International Master Science Program in Reconstructive Microsurgery College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherng\u2010Shyang","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-5894","authenticated-orcid":false,"given":"Chung\u2010Kan","family":"Tsao","sequence":"additional","affiliation":[{"name":"International Master Science Program in Reconstructive Microsurgery College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Center for Tissue Engineering Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"},{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson JM","year":"2008","journal-title":"Semin Immunol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.actbio.2024.06.013","article-title":"Conserved and tissue\u2010specific immune responses to biologic scaffold implantation","volume":"184","author":"DeStefano S","year":"2024","journal-title":"Acta Biomater"},{"issue":"17","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301939","article-title":"Unraveling and harnessing the immune response at the cell\u2010biomaterial Interface for tissue engineering purposes","volume":"13","author":"Ten Brink T","year":"2024","journal-title":"Adv 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