{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:49:10Z","timestamp":1791442150548,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272580"],"award-info":[{"award-number":["82272580"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002373"],"award-info":[{"award-number":["82002373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["B202304070041"],"award-info":[{"award-number":["B202304070041"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["Innovation\u2010Driven Project"],"award-info":[{"award-number":["Innovation\u2010Driven Project"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp;amp; Transla Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteogenesis is a crucial process in bone injury repair where osteoblasts mineralize collagen to form new bone at the fracture site. For effective bone regeneration in comminuted fractures, it is essential to develop an osteogenic bone adhesive that can be applied at the time of fixation to temporarily immobilize fragmented bone pieces. We present a flowable, injectable adhesive that enables on\u2010demand bonding of irregular fracture surfaces and, after photocuring, provides enhanced mechanical integrity while supporting osteogenesis. To meet these clinical requirements, we engineered a gelatin methacryloyl\u2013polyethylene glycol diacrylate (GelMA\u2013PEGDA) network bone adhesive that undergoes rapid photocuring to enable on\u2010demand bonding and immediate mechanical stabilization at the fracture site. By incorporating nanoscale hydroxyapatite (nHA) to confer a bone\u2010mineral\u2010mimetic composition and biomineralization capacity, the photocured adhesive promotes bone marrow\u2010derived mesenchymal stem cell recruitment and supports skeletal regeneration. During degradation, the organic\u2013inorganic phase of the adhesive can guide osteogenesis, leading to satisfactory healing outcomes in fractures. Overall, the compositional and mechanical biomimicry, photosensitivity and osteogenic potential of GelMA\u2013nHA\u2013PEGDA render it a potential all\u2010in\u2010one solution for minimally invasive treatment of multiple skeletal diseases.<\/jats:p>","DOI":"10.1002\/btm2.70182","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:32Z","timestamp":1791438572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An osteogenesis mimicking biomineralized bone adhesive for rapid skeletal regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1360-8165","authenticated-orcid":false,"given":"Yuqi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"AO Research Institute Davos  Davos Platz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1605-7516","authenticated-orcid":false,"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-1517","authenticated-orcid":false,"given":"Martin J.","family":"Stoddart","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos  Davos Platz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-6990","authenticated-orcid":false,"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos  Davos Platz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xucheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102465"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032868\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201802021"},{"issue":"5","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201908381","article-title":"Bioinspired mineral\u2013organic bone adhesives for stable fracture fixation and accelerated bone regeneration","volume":"30","author":"Bai S","year":"2020","journal-title":"Adv Funct Mater"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010022\u201000190\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204592"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl9653"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010021\u201000477\u20102"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003882"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201602628"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.06.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011455\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115832"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020944"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.08.045"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021964\u20100"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007457"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026464\u20109"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200152"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13173735"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121741"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014000\u20109"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57656","article-title":"Aberrant subchondral osteoblastic metabolism modifies NaV1. 8 for osteoarthritis","volume":"9","author":"Zhu J","year":"2020","journal-title":"Elife"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121561"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014153\u20107"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010014\u20100076\u20105"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907491"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.03.019"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stam.2006.11.017"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsamd.2022.100485"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400559g"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001058"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035231163273"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600902"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010023\u201006714\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.14744\/tjtes.2021.02575"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1461260"}],"container-title":["Bioengineering &amp; Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/btm2.70182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/btm2.70182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/btm2.70182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:34Z","timestamp":1791438574000},"score":1,"resource":{"primary":{"URL":"https:\/\/aiche.onlinelibrary.wiley.com\/doi\/10.1002\/btm2.70182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":39,"alternative-id":["10.1002\/btm2.70182"],"URL":"https:\/\/doi.org\/10.1002\/btm2.70182","archive":["Portico"],"relation":{},"ISSN":["2380-6761","2380-6761"],"issn-type":[{"value":"2380-6761","type":"print"},{"value":"2380-6761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70182"}}