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In this work, the ability of a wide range of ILs to form ABS with aqueous solutions of Na<jats:sub>2<\/jats:sub>CO<jats:sub>3<\/jats:sub> was evaluated. The ABS formed by IL\u2009+\u2009water\u2009+\u2009Na<jats:sub>2<\/jats:sub>CO<jats:sub>3<\/jats:sub> were determined at 25\u00b0C, and the respective solubility curves, tie\u2010lines, and tie\u2010line lengths are reported. The studied ILs share the common chloride anion, allowing the IL cation core, the cation isomerism, the presence of functionalized groups, and alkyl side chain length effects to be evaluated. An increase in the cation side alkyl chain length leads to a higher ability for liquid\u2013liquid demixing whereas different positional isomers and the presence of an allyl group have no major influence in the phase diagrams behavior. Quaternary phosphonium\u2010 and ammonium\u2010based fluids are more able to form an ABS when compared with imidazolium\u2010, pyridinium\u2010, pyrrolidinium\u2010, and piperidium\u2010based ILs. Moreover, the presence of an aromatic cation core has no major contribution to the formation of ABS when compared to the respective nonaromatic counterparts. Finally, to appraise on the systems applicability in downstream processing, selected systems were used for the partitioning of tetracyclines (neutral and salt forms) \u2014 a class of antibiotics produced by bacteria fermentation. Single\u2010step extraction efficiencies for the IL\u2010rich phase were always higher than 99% and confirm the great potential of ILs to be applied in the biotechnological field. \u00a9 2013 American Institute of Chemical Engineers <jats:italic>Biotechnol. Prog<\/jats:italic>., 29:645\u2013654, 2013<\/jats:p>","DOI":"10.1002\/btpr.1708","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T10:32:16Z","timestamp":1361269936000},"page":"645-654","source":"Crossref","is-referenced-by-count":51,"title":["Aqueous biphasic systems composed of ionic liquids and sodium carbonate as enhanced routes for the extraction of tetracycline"],"prefix":"10.1002","volume":"29","author":[{"given":"Carlos F. C.","family":"Marques","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, CICECO Universidade de Aveiro 3810\u2010193 Aveiro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, CICECO Universidade de Aveiro 3810\u2010193 Aveiro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina M. S. 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