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The need for the optimization of bioprocesses such as ethanol production, to increase product yield, enhanced the development of control strategies. The control system developed by the authors utilized noninvasive Raman measurements to avoid possible sterilization problems. Real\u2010time data analysis was applied using partial least squares regression (PLS) method. With the aid of spectral pretreatment and multivariate data analysis, the monitoring of glucose and ethanol concentration was successful during yeast fermentation with the prediction error of 4.42\u2009g\/L for glucose and 2.40\u2009g\/L for ethanol. By Raman spectroscopy\u2010based feedback control, the glucose concentration was maintained at 100\u2009g\/L by the automatic feeding of concentrated glucose solution. The control of glucose concentration during fed\u2010batch fermentation resulted in increased ethanol production. Ethanol yield of 86% was achieved compared to the batch fermentation when\n                    <jats:styled-content>75<\/jats:styled-content>\n                    % yield was obtained. The results show that the use of Raman spectroscopy for the monitoring and control of yeast fermentation is a promising way to enhance process understanding and achieve consistently high production yield.\n                  <\/jats:p>","DOI":"10.1002\/btpr.2848","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T06:50:28Z","timestamp":1558507828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Inline noninvasive Raman monitoring and feedback control of glucose concentration during ethanol fermentation"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-9572","authenticated-orcid":false,"given":"Edit","family":"Hirsch","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajnalka","family":"Pataki","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Domj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panna","family":"Vass","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Applied Biotechnology and Food Science Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Barta","sequence":"additional","affiliation":[{"name":"Department of Applied Biotechnology and Food Science Budapest University of Technology and Economics  Budapest Hungary"},{"name":"Viresol Ltd.  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