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Human transmission of this virus occurs via respiratory droplets from symptomatic and asymptomatic patients, which are released into the environment after sneezing or coughing. These droplets are capable of staying in the air as aerosols or surfaces and can be transmitted to persons through inhalation or contact with contaminated surfaces. Thus, there is an urgent need for advanced theranostic solutions to control the spread of COVID\u201019 infection. The development of such fit\u2010for\u2010purpose technologies hinges on a proper understanding of the transmission, incubation, and structural characteristics of the virus in the external environment and within the host. Hence, this article describes the development of an intrinsic model to describe the incubation characteristics of the virus under varying environmental factors. It also discusses on the evaluation of SARS\u2010CoV\u20102 structural nucleocapsid protein properties via computational approaches to generate high\u2010affinity binding probes for effective diagnosis and targeted treatment applications by specific targeting of viruses. In addition, this article provides useful insights on the transmission behavior of the virus and creates new opportunities for theranostics development.<\/jats:p>","DOI":"10.1002\/btpr.3096","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T05:17:36Z","timestamp":1603948656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biophysical analysis of\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 transmission and theranostic development via N protein computational characterization"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-1715","authenticated-orcid":false,"given":"Godfred O.","family":"Sabbih","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering University of Tennessee  Chattanooga Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maame 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