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Montmorillonite (MMT) nanoparticles were added to chitosan (CS)\u2010agarose (Aga) hydrogel and then loaded with curcumin (Cur) to prepare a curcumin\u2010loaded nanocomposite hydrogel. The loading capacity increased from 63% to 76% by adding MMT nanoparticles to a chitosan\u2010agarose hydrogel. Loading the fabricated nanocomposite in the nanoniosomal emulsion resulted in sustained release of curcumin under acidic conditions. Release kinetics analysis showed diffusion and erosion are the dominant release mechanisms, indicating non\u2010fickian (or anomalous) transport based on the Korsmeyer\u2010Peppas model. FTIR spectra confirmed that all nanocomposite components were present in the fabricated nanocomposite. Besides, XRD results corroborated the amorphous structure of the prepared nanocomposite. Zeta potential results corroborated the stability of the fabricated nanocarrier. Cytotoxicity of the prepared CS\u2010Aga\u2010MMT\u2010Cur on MCF\u20107 cells was comparable with that of curcumin\u2010treated cells (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u20090.001). Moreover, the percentage of apoptotic cells increased due to the enhanced release profile resulting from the addition of MMT to the hydrogel and the incorporation of the fabricated nanocomposite into the nanoniosomal emulsion. To recapitulate, the current delivery platform improved loading, sustained release, and curcumin anti\u2010cancer effect. Hence, this platform could be a potential candidate to mitigate cancer therapy restrictions with curcumin.\n                  <\/jats:p>","DOI":"10.1002\/btpr.3280","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:36:50Z","timestamp":1654771010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["RETRACTED: A novel\n                    <scp>pH<\/scp>\n                    \u2010responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan\u2010based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction"],"prefix":"10.1002","volume":"38","author":[{"given":"Shabnam","family":"Haseli","sequence":"first","affiliation":[{"name":"Department of Biotechnology, School of Chemical Engineering, College of Engineering University of Tehran  Tehran 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