{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:58Z","timestamp":1786977298393,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A2C2090053"],"award-info":[{"award-number":["NRF\u20102019R1A2C2090053"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Progress"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood shortages for transfusion are global issues of grave concern. As in vitro manufactured platelets are promising substitutes for blood donation, recent research has shown progresses including different cell sources, different bioreactors, and three\u2010dimensional materials. The first\u2010in\u2010human clinical trial of cultured platelets using induced pluripotent stem cell\u2010derived platelets began in Japan and demonstrated its quality, safety, and efficacy. A novel bioreactor with fluid motion for platelet production has been reported. Herein, we discuss various cell sources for blood cell production, recent advances in manufacturing processes, and clinical applications of cultured blood.<\/jats:p>","DOI":"10.1002\/btpr.3364","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:54:00Z","timestamp":1686297240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Current status of platelet manufacturing in\n                    <scp>3D<\/scp>\n                    or bioreactors"],"prefix":"10.1002","volume":"39","author":[{"given":"Soonho","family":"Kweon","sequence":"first","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-3132","authenticated-orcid":false,"given":"Suyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongwon","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Research and Development ArtBlood Inc  Seoul Republic of Korea"},{"name":"Department of Translational Medicine Graduate School of Biomedical Science and Engineering, Hanyang University  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003715"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.12843"},{"key":"e_1_2_9_4_1","first-page":"2252","article-title":"In vitro generation of megakaryocytes and platelets","volume":"9","author":"Liu H","year":"2021","journal-title":"Front Cell Dev 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