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Psilocybin, a notable tryptamine, has garnered attention for its therapeutic potential in treating mental health disorders like depression and anxiety. Despite its promising applications, current extraction methods for psilocybin are labor\u2010intensive and economically limiting. We suggest biocatalysis as a sustainable alternative, leveraging enzymes to synthesize psilocybin and other tryptamines efficiently. By elucidating psilocybin biosynthesis pathways, researchers aim to advance synthetic methodologies and industrial applications. This review underscores the transformative potential of biocatalysis in enhancing our understanding of tryptamine biosynthesis and facilitating the production of high\u2010purity psilocybin and other tryptamines for therapeutic and research use.<\/jats:p>","DOI":"10.1002\/btpr.3513","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T22:24:37Z","timestamp":1728080677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-6900","authenticated-orcid":false,"given":"Lucas Henrique","family":"Junges","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Nitrogen Fixation Laboratory Federal University of Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9615-6007","authenticated-orcid":false,"given":"Marcelo","family":"M\u00fcller\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Nitrogen Fixation Laboratory Federal University of Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149\u20107634(82)90030\u20106"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.315"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239279"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010015\u20101513\u2010x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18066620"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"RogersSA HellerEA CorderG.Psilocybin\u2010enhanced fear extinction linked to bidirectional modulation of cortical ensembles. bioRxiv (Cold Spring Harbor Laboratory). 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