{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:38:29Z","timestamp":1705001909844},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anomalies of the extraocular muscles have been suspected to be present frequently in patients with craniofacial malformations. We studied the extraocular musculature in the orbits of 15 anencephalic human fetuses between the 5th and 10th months after gestation, and in one fetus with an occipital meningocele and a large defect of the left cranial base. The findings were compared to those in nine normal age\u2010matched fetuses. All malformed fetuses exhibited special features of the levator palpebrae superioris muscle, either its absence, an anomaly of the muscle belly, or an anomalous insertion. In addition, deficient or aberrant muscle bellies of the oblique and rectus muscles were found. In anencephaly, the frontal bone is condensed, forming narrowed orbital cavities with hypotelorism. Frequent disturbance of extraocular muscle development in fetuses with craniofacial malformations is implicated. The presented specimens are examples of extreme variants of cranial and craniofacial malformation syndromes. Thus, similar findings of extraocular muscles might also be regularly found in clinically relevant craniofacial malformations. This would force new considerations about diagnostic and therapeutic approaches to patients with craniofacial malformations. Clin. Anat. 20:239\u2013245, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ca.20404","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T21:22:21Z","timestamp":1161984141000},"page":"239-245","source":"Crossref","is-referenced-by-count":8,"title":["Extraocular eye muscles in human fetuses with craniofacial malformations: Anatomical findings and clinical relevance"],"prefix":"10.1002","volume":"20","author":[{"given":"J.","family":"Plock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Contaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Von L\u00fcdinghausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.7.638"},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Beitrag zu den anomalen Muskeln in der Augenh\u00f6hle","volume":"4","author":"Bochdalek VA","year":"1868","journal-title":"Prager Vierteljahresschrift"},{"key":"e_1_2_1_4_1","first-page":"273","article-title":"Beschreibung eines neuen Muskels und mehrerer Muskel\u2010 und Knochenvariet\u00e4ten","volume":"3","author":"Budge J","year":"1859","journal-title":"Z Ration Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02181187"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(99)70059-5"},{"key":"e_1_2_1_7_1","first-page":"241","volume-title":"Anatomie. 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