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Pathologic mechanical forces alone (overstretching and\/or ischemia from direct compression) may not fully explain postsurgical neuropathy with recent evidence implicating patient\u2010specific factors or perioperative inflammatory responses spatially and even temporally divorced from the anatomical region of injury. The aim of this introductory article is to provide an overview of anatomic considerations of these mechanical forces on soft and nervous tissues along with factors that may compound compression or stretch injury. Three subsequent articles will address specific positioning\u2010related anatomic considerations of the (1) upper extremities, (2) lower extremities, and (3) central nervous system and soft tissues. Clin. 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