{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:52:06Z","timestamp":1789213926975,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Osteogenesis imperfecta (OI), also known as Lobstein's syndrome or Vrolik's syndrome, comprises a heterogeneous group of rare genetic connective tissue disorders. It is characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures of variable severity. Originally named \u201costeomalacia congenita,\u201d the condition was first medically described in a family by Ekman in 1778. Here, we report a 17th century medical account from France, which predates Eckman's doctoral dissertation by about a century. Medical analysis of this anatomical presentation indicates a precise diagnosis of Type I OI. Clin. Anat. 30:128\u2013129, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ca.22806","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T23:23:48Z","timestamp":1478561028000},"page":"128-129","source":"Crossref","is-referenced-by-count":5,"title":["Oldest medical description of osteogenesis imperfecta (17th Century, France)"],"prefix":"10.1002","volume":"30","author":[{"given":"Philippe","family":"Charlier","sequence":"first","affiliation":[{"name":"Section of Medical and Forensic Anthropology (UVSQ &amp; Paris\u2010Descartes University EA 4569) Montigny\u2010Le\u2010Bretonneux France"},{"name":"CASH &amp; IPES Nanterre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Perciaccante","sequence":"additional","affiliation":[{"name":"Department of Medicine \u201cSan Giovanni di Dio\u201d Hospital Gorizia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Bianucci","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences Legal Medicine Section, University of Turin  Italy"},{"name":"UMR 7268 Laboratoire d'Anthropologie Bio\u2010culturelle, Droit, Etique &amp; Sant\u00e9 (Ad\u00e9s), Facult\u00e9 de M\u00e9decine de Marseille  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200002060-00005"},{"key":"e_1_2_2_3_1","first-page":"58","article-title":"Merkw\u00fcrdige fragilit\u00e4t der Knochen ohne dyskrastische Ursache als krankhafte Eigenth\u00fcmlichkeit dreier Geschwister","volume":"4","author":"Axmann E.","year":"1831","journal-title":"Ann Ges Heilk Karlsruhe"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(02)80023-1"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(08)71912-2"},{"key":"e_1_2_2_6_1","unstructured":"BudayK.1895Beitr\u00e4ge zur Lehore von der Osteogenesis Imperfecta."},{"key":"e_1_2_2_7_1","unstructured":"EkmanOJ.1788Dissertatio medica descriptionem et casus aliquot osteomalaci\u00e6 sistens. Upsali\u00e6 J. Edman."},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00728-X"},{"key":"e_1_2_2_9_1","volume-title":"Lehrbuch der pathologischen Anatomie","author":"Lobstein JF.","year":"1835"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-009-0817-7"},{"key":"e_1_2_2_11_1","unstructured":"NIH\/National Institute of Health.2015. Osteogenesis Imperfecta Overview. At:http:\/\/www.niams.nih.gov\/Health_Info\/Bone\/Osteogenesis_Imperfecta\/overview.asp. Accessed on Sept 8 2016."},{"key":"e_1_2_2_12_1","unstructured":"ORPHA\u2010NET.2010.http:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?Expert=666Accessed on Sept 82016."},{"key":"e_1_2_2_13_1","unstructured":"Saviard.1691. Extrait d'une lettre de Monsieur Saviard Ma\u00eetre\u2010chirurgien jur\u00e9 de Paris et de l'H\u00f4tel\u2010Dieu. Journal des savants 5th February47\u201348."},{"key":"e_1_2_2_14_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00003086-198109000-00004","article-title":"Osteogenesis imperfecta: An expanding panorama of variants","volume":"159","author":"Sillence D.","year":"1981","journal-title":"Clin Orthop"},{"key":"e_1_2_2_15_1","unstructured":"VrolikW.1849. Tabulae ad illustrandam embryogenesin hominis et mammalium tam naturalem quam abnormem. G. M. P. Londinck."}],"container-title":["Clinical Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fca.22806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.22806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:02:42Z","timestamp":1695571362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ca.22806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,25]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/ca.22806"],"URL":"https:\/\/doi.org\/10.1002\/ca.22806","archive":["Portico"],"relation":{},"ISSN":["0897-3806","1098-2353"],"issn-type":[{"value":"0897-3806","type":"print"},{"value":"1098-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,25]]}}}