{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:14Z","timestamp":1786977314042,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL102119"],"award-info":[{"award-number":["R01 HL102119"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH107571"],"award-info":[{"award-number":["R01 MH107571"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Several studies have used a variety of neuroimaging techniques to measure brain activity during the voiding phase of micturition. However, there is a lack of consensus on which regions of the brain are activated during voiding. The aim of this meta\u2010analysis is to identify the brain regions that are consistently activated during voiding in healthy adults across different studies. We searched the literature for neuroimaging studies that reported brain co\u2010ordinates that were activated during voiding. We excluded studies that reported co\u2010ordinates only for bladder filling, during pelvic floor contraction only, and studies that focused on abnormal bladder states such as the neurogenic bladder. We used the activation\u2010likelihood estimation (ALE) approach to create a statistical map of the brain and identify the brain co\u2010ordinates that were activated across different studies. We identified nine studies that reported brain activation during the task of voiding in 91 healthy subjects. Together, these studies reported 117 foci for ALE analysis. Our ALE map yielded six clusters of activation in the pons, cerebellum, insula, anterior cingulate cortex (ACC), thalamus, and the inferior frontal gyrus. Regions of the brain involved in executive control (frontal cortex), interoception (ACC, insula), motor control (cerebellum, thalamus), and brainstem (pons) are involved in micturition. This analysis provides insight into the supraspinal control of voiding in healthy adults and provides a framework to understand dysfunctional voiding. Clin. Anat., 2018. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ca.23244","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T09:22:49Z","timestamp":1533288169000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Brain activation during the voiding phase of micturition in healthy adults: A meta\u2010analysis of neuroimaging studies"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-464X","authenticated-orcid":false,"given":"Camryn","family":"Harvie","sequence":"first","affiliation":[{"name":"Division of Urogynecology, Department of Obstetrics and Gynecology Hospital of University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Weissbart","sequence":"additional","affiliation":[{"name":"Department of Urology Stony Brook School of Medicine Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-8960","authenticated-orcid":false,"given":"Priyanka","family":"Kadam\u2010Halani","sequence":"additional","affiliation":[{"name":"Division of Urogynecology, Department of Obstetrics and Gynecology Hospital of University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Rao","sequence":"additional","affiliation":[{"name":"Center for Functional Neuroimaging University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily A.","family":"Arya","sequence":"additional","affiliation":[{"name":"Division of Urogynecology, Department of Obstetrics and Gynecology Hospital of University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.11.019"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22840"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23058"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)13384-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.111"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.11.2033"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn894"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/j.2040-4603.2015.tb00596.x","article-title":"Neural control of the lower urinary tract","volume":"5","author":"Groat WC","year":"2015","journal-title":"Compr Physiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20718"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.017"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20613"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199611250-00042"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12019"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.061"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-002-0604-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902500404"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0b013e3182065507"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.04.004"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4404"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu140"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64846-X"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90604-T"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.4.781"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.277"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.286"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1996)15:6<599::AID-NAU2>3.0.CO;2-A"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1642-z"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00872.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.012"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.044"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.04.090"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.053"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21186"}],"container-title":["Clinical Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fca.23244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.23244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T01:58:09Z","timestamp":1751767089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ca.23244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/ca.23244"],"URL":"https:\/\/doi.org\/10.1002\/ca.23244","archive":["Portico"],"relation":{},"ISSN":["0897-3806","1098-2353"],"issn-type":[{"value":"0897-3806","type":"print"},{"value":"1098-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"2018-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}