{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:57Z","timestamp":1786977297818,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    Unilateral cleft lip and palate (UCLP) is a craniofacial deformity characterized by lip and palate clefting on one side of the face. UCLP originates from failures in neural crest migration and differentiation during embryological development, impairing facial primordia fusion (medial nasal, maxillary, and lateral processes) resulting in clefting. Persons with UCLP experience issues in nasal breathing, speaking, and mastication. Facial directional asymmetry (DA), consisting of left\u2013right side differences biased toward one particular side, can arise from environmental or hereditary factors. This retrospective, cross\u2010sectional study, quantifies DA in the facial skeleton of children with surgically repaired UCLP. We tested the hypothesis that DA is significantly increased in persons with UCLP. Twenty\u2010three anatomical landmark coordinates were measured from cone beam computed tomography images of two age\u2010 and sex\u2010matched samples: (1) persons with UCLP post\u2010surgery (\n                    <jats:italic>n<\/jats:italic>\n                    = 26, 7\u201317 years); (2) typical children (\n                    <jats:italic>n<\/jats:italic>\n                    = 26, 7\u201317 years). From these coordinates, 81 bilateral paired measurements were calculated and statistically assessed for DA differences using Principal Components Analysis and Euclidean Distance Matrix Analysis. Samples separate in high\u2010dimensional space and 35.8% of bilateral measures are statistically significant. Patterns of significant DA differences between samples were explored based on magnitude. Compared with the control group, in all but five cases, significant DA was greater in persons with UCLP. Regions derived from the maxillary and nasal prominences demonstrated the most DA. These results are important for medical practitioners for identifying the extent to which patients with UCLP deviate from the norm. Clin. Anat. 31:1129\u20131136, 2018. \u00a9 2018 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ca.23277","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T12:20:24Z","timestamp":1536668424000},"page":"1129-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disruption of symmetry: A quantitative assessment of facial skeleton anatomy in children born with unilateral cleft lip and palate"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-6325","authenticated-orcid":false,"given":"Yaser","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Central Florida  Orlando Florida 32816"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Starbuck","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Central 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