{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:10:33Z","timestamp":1762409433491,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007900","name":"University of Central Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Unilateral cleft lip and palate (UCLP) is a congenital deformity that occurs due to inadequate merging of the nasal and maxillary prominences during fetal development. Randomly distributed bilateral asymmetries known as fluctuating asymmetry (FA) occur in normally symmetric organisms when evolved mechanisms of developmental stability or equilibrium are disturbed by genetic, environmental, or unknown factors. Here, we hypothesize that facial skeleton FA will be increased in a sample of individuals born with UCLP (<jats:italic>n<\/jats:italic> = 24) relative to sex\u2010 and age\u2010matched controls (<jats:italic>n<\/jats:italic> = 24). To test this hypothesis, 23 anatomical landmarks were measured on individual anonymized cone\u2010beam computerized tomography (CBCT) images in children and adolescents (7\u201317 years). For each individual, 81 pairs of linear distances were used to estimate FAs across the face. To explore sample variation and statistical differences, a principal components analysis and Euclidean Distance Matrix Analysis multivariate bootstrap approach were carried out. Samples show some separation in multivariate space with 44.44% of FA differences being significantly different. The magnitude of FA was larger in the UCLP sample for every significant measurement. The magnitude of significant FA is highest near regions derived from the maxillary and nasal prominences, such as the nasal aperture. These results are useful for medical and dental practitioners when developing treatment options for children and adolescents with UCLP. Clin. Anat. 32:206\u2013211, 2019. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ca.23281","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T15:52:53Z","timestamp":1537890773000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A morphometric analysis of developmental instability in children born with unilateral cleft lip and palate"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-5760","authenticated-orcid":false,"given":"Kristyna","family":"Ceuninck","sequence":"first","affiliation":[{"name":"Department of Anthropology University of Central Florida  Orlando Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Starbuck","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Central Florida  Orlando 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