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Consequently, researchers are seeking alternative embalming techniques that better preserve <jats:italic>in vivo<\/jats:italic> characteristics of tissues. Phenol\u2010based embalming is one method that has shown promise in its ability to adequately preserve the <jats:italic>in vivo<\/jats:italic> qualities of tissues through preliminary explorations at the gross anatomical level. The literature on phenol\u2010based embalming is currently scarce, especially with regard to its effects on tissues at the microscopic level. For the current study we aimed to document the histologic effects of a formaldehyde\u2010free phenol\u2010based embalming solution on neural tissue, with the hope of providing novel insight into the effects of soft\u2010embalming on tissues at the microscopic level. Cerebral and cerebellar tissue obtained from porcine brains was fixed in phenol\u2010 and formaldehyde\u2010based fixatives; the latter served as a control. Fixed samples were processed for histological analysis. The phenol\u2010based embalming solution provided excellent preservation of the cerebral and cerebellar tissue morphology. Of note was the decrease in separation artifact seen in both tissue types relative to the control tissue, as well as anomalous circular artifacts in the white matter. The results of this study indicate that the phenol\u2010based embalming solution preserves neural tissue at the histological level, perhaps superiorly in many aspects when compared to the formaldehyde\u2010fixed samples. Further investigations of both gross anatomy and histology are recommended on the basis of these promising new findings to determine its potential utilities within research and education. Clin. 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