{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:31:11Z","timestamp":1777501871241,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The so\u2010called membranous septum is the fibrous component of the septal structures within the heart. It is relatively subtle in its appearance, but of considerable significance to the understanding of cardiac function and cardiac disease, both congenital and acquired. Surprisingly, its existence was seemingly unknown until the early decades of the 19th century. At this time, those writing in the English language described it as the \u201cundefended space,\u201d recognizing its importance in the setting of its aneurysmal dilation, and as the site of septal defects. By the initial decade of the 20th century, it had come to be recognized as the landmark to the site of atrioventricular bundle. Over the first decade of the 21st century, its clinical significance has been emphasized in the context of transcutaneous replacement of the aortic valve. In this review, we describe our own recent investigations of this fibrous part of the septal structures. At the same time, we provide a glimpse of our anatomic past, explaining how its initial description relied on the observations of young physicians taking their first steps in the investigation of cardiac anatomy.<\/jats:p>","DOI":"10.1002\/ca.23599","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T03:44:35Z","timestamp":1586144675000},"page":"178-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The membranous septum revisited: A glimpse of our anatomical past"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8128-2163","authenticated-orcid":false,"given":"Marcos C.","family":"De Almeida","sequence":"first","affiliation":[{"name":"Department of Genetics and Morphology Brasilia's University  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Sanchez\u2010Quintana","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Biology, Faculty of Medicine University of Extremadura  Badajoz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-9021","authenticated-orcid":false,"given":"Robert H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine, Newcastle University  Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2016.06.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195809000-00012"},{"key":"e_1_2_7_4_1","first-page":"133","article-title":"Ueber den Durchbruch des Septum ventriculorum cordis","volume":"9","author":"Hauschka D. J.","year":"1855","journal-title":"Wien Medizin Wochschriften"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2000.tb00741.x"},{"key":"e_1_2_7_6_1","first-page":"639","volume-title":"A treatise on diseases of the heart and great vessels","author":"Hope J.","year":"1839"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7767\/9783205232773","volume-title":"Die Josephs\u2010Akademie Im Wiener Josephinum","author":"Lohff B.","year":"2019"},{"key":"e_1_2_7_8_1","first-page":"245","volume-title":"Tracing archaeology's past: The historiography of archaeology","author":"McVicker D.","year":"1989"},{"key":"e_1_2_7_9_1","first-page":"60","article-title":"Malformations of the heart consisting in an imperfection of the auricular and ventricular septa","volume":"1","author":"Peacock T. B.","year":"1846","journal-title":"Transaction of Pathological Society of London"},{"key":"e_1_2_7_10_1","first-page":"49","article-title":"Endocarditis; Destruction of one of the aortic valves, and partial perforation of the septum of the ventricles, fatty degeneration","volume":"2","author":"Peacock T. B.","year":"1849","journal-title":"Transaction of Pathological Society of London"},{"key":"e_1_2_7_11_1","first-page":"222","article-title":"Vorlesungen \u00fcber die Missbildungen des Herzens gehalten im St Thomas Hospital","volume":"24","author":"Peacock T. B.","year":"1855","journal-title":"Jounal f\u00fcr KinderKrankheiten"},{"key":"e_1_2_7_12_1","first-page":"143","volume-title":"On malformations of the human heart with original cases","author":"Peacock T. B.","year":"1858"},{"key":"e_1_2_7_13_1","first-page":"769","volume-title":"Trait\u00e9 DAnatomie Humaine,T.II Angeiologie","author":"Poirier P.","year":"1902"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0025727300027393"},{"key":"e_1_2_7_15_1","first-page":"910","volume-title":"Elements of anatomy","author":"Quain J.","year":"1837"},{"key":"e_1_2_7_16_1","first-page":"85","article-title":"Congenital malformation of the heart in a youth","volume":"7","author":"Quain J.","year":"1856","journal-title":"Transaction of Pathological Society of London"},{"key":"e_1_2_7_17_1","first-page":"1015","volume-title":"The cyclopaedia of anatomy and physiology","author":"Reid J.","year":"1839"},{"key":"e_1_2_7_18_1","first-page":"129","article-title":"Zur anatomischen und pathologischen Kenntniss der d\u00fcnne Stelle in der Herzscheidewand (Pars membranacea septi ventriculorum)","volume":"12","author":"Reinhard H.","year":"1857","journal-title":"Archiv f\u00fcr pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin"},{"key":"e_1_2_7_19_1","first-page":"156","volume-title":"Die Defecte der Scheidew\u00e4nde des Herzens. Pathologisch\u2010Anatomische Abhandlung","author":"Rokitansky K.","year":"1875"},{"key":"e_1_2_7_20_1","first-page":"9","article-title":"The membranous ventricular septum in the normal heart","volume":"135","author":"Rosenquist G. C.","year":"1974","journal-title":"The Johns Hopkins Medical Journal"},{"key":"e_1_2_7_21_1","first-page":"279","volume-title":"Anatomie Des Herzens","author":"Tandler J.","year":"1913"},{"key":"e_1_2_7_22_1","volume-title":"Das Reizleitungssystem Des S\u00e4ugetierherzens. Eine Anatomisch\u2010Histologische Studie \u00dcber Das Atrioventrikularb\u00fcndel Und Die Purkinjeschen F\u00e4den","author":"Tawara S.","year":"1906"},{"key":"e_1_2_7_23_1","volume-title":"The conduction system of the mammalian heart: An anatomico\u2010histological study of the atrioventricular bundle and the Purkinje fibers","author":"Tawara S.","year":"1998"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/095952873802100114"},{"key":"e_1_2_7_25_1","first-page":"1015","volume-title":"The cyclopaedia of anatomy and physiology","author":"Todd R.","year":"1839"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000972"},{"key":"e_1_2_7_27_1","volume-title":"Dictionary of National Biography","author":"Urquhart A. R.","year":"1900"},{"key":"e_1_2_7_28_1","first-page":"269","article-title":"Zur Geschichte der Pars membranacea septi cordis","volume":"13","author":"Virchow R.","year":"1858","journal-title":"Archiv f\u00fcr pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980070602"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.28.4.435"}],"container-title":["Clinical Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fca.23599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.23599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ca.23599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.23599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:39:40Z","timestamp":1737117580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ca.23599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/ca.23599"],"URL":"https:\/\/doi.org\/10.1002\/ca.23599","archive":["Portico"],"relation":{},"ISSN":["0897-3806","1098-2353"],"issn-type":[{"value":"0897-3806","type":"print"},{"value":"1098-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]},"assertion":[{"value":"2020-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}