{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T05:12:35Z","timestamp":1737177155845,"version":"3.33.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Currently, diagnosis of acute appendicitis (AA) is challenging. Here, we aim to propose using the new palpation sign to diagnose AA and establish the effectiveness of clinical examination using a proprietary diagnostic palpation procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively analyzed 2,883 patients of all ages who were examined for suspected AA, of whom 532 patients required surgical intervention, using the new palpation sign. Patients were divided into three age categories. Based on the correlation between clinical data and histological findings, clinical examination finding was defined as false negative, false positive, and positive. Pearson correlation analysis was performed to assess the correlation between patients' sex and age distribution and clinical and histological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a strong correlation (<jats:italic>r<\/jats:italic>\u2009&gt;\u2009.95) for distribution of total number of examined patients (distributed in groups by sex and age) versus false\u2010positive clinical findings, total number of examined patients (distributed in groups by sex and age) versus positive clinical findings, and total number of examined patients (distributed in groups by age) versus histology in phlegmonous and gangrenous appendicitis. Correlations (<jats:italic>r<\/jats:italic> = .94 and .90) were observed for distribution of total number of examined patients (distributed in groups by age) versus negative histological findings and Byron's obliterating appendicopathy. Pearson's chi\u2010squared test showed no significant difference between expected and observed frequencies of both clinical and histologic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new palpation sign can be used to diagnose early and later stage appendicitis, especially in children and young women, and is very effective in indicating surgery for AA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ca.23684","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T18:16:18Z","timestamp":1601316978000},"page":"218-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute appendicitis: Clinical anatomy of the new palpation sign"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-2007","authenticated-orcid":false,"given":"Vitezslav","family":"Marek","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology St. Elizabeth Hospital, Medical School of Comenius University  Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Z\u00e1horec","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive medicine St. Elizabeth Hospital, Medical School of Comenius University  Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Durd\u00edk","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology St. Elizabeth Hospital, Medical School of Comenius University  Bratislava Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"173","article-title":"CT and ultrasonography in the diagnosis of equivocal acute appendicitis. 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