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However, there is little accurate knowledge of the anatomical parameters that constitute cervical lordosis (i.e., the sagittal wedging angles of intervertebral discs and vertebral bodies) and their associations with age and sex. Standing lateral cervical radiographs of 1020 subjects (424 males, 596 females) with a mean age of 36.6\u2009\u00b1\u200917.0\u2009years (range 7\u201395\u2009years) were evaluated retrospectively. Cervical lordosis, the sum of intervertebral disc wedging angles from C2\/C3 to C6\/C7 and the sum of vertebral body wedging angles from C3 to C7 were measured. The sum of intervertebral disc wedging and the sum of vertebral body wedging were 20.6\u00b0\u2009\u00b1\u200914.7\u00b0 and \u221212.8\u00b0\u2009\u00b1\u200910.3\u00b0, respectively. The sum of intervertebral disc wedging increased significantly with age and was significantly greater in males than females, whereas there was no sex\u2010related difference in the sum of vertebral body wedging. The sum of intervertebral disc wedging was negatively correlated with sum of vertebral body wedging. Wedging of discs contributed to C2\u2013C7 cervical lordosis more significantly than wedging of vertebral bodies. There were moderate positive correlations between cervical lordosis and intervertebral disc wedging angles at C3\/C4, C4\/C5 and C5\/C6; weak correlations were observed at C2\/C3 and C6\/C7. This study constitutes the largest currently available analysis comprehensively documenting the anatomical characteristics of sagittal wedging of intervertebral discs and vertebral bodies in the cervical spine. The findings could improve understanding of the internal architecture of cervical lordosis among clinicians.<\/jats:p>","DOI":"10.1002\/ca.23769","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:43:41Z","timestamp":1627299821000},"page":"1111-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sagittal wedging of intervertebral discs and vertebral bodies in the cervical spine and their associations with age, sex and cervical lordosis: A large\u2010scale morphological study"],"prefix":"10.1002","volume":"34","author":[{"given":"Youping","family":"Tao","sequence":"first","affiliation":[{"name":"Institute of Orthopaedic Research and Biomechanics, Trauma Research Center Ulm Ulm University Medical Centre  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Institute of 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