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Therefore, the control of osteoporosis and bone fracture is important for healthy life expectancy, and the fundamental understanding of its pathogenesis and its application in treatment is of great social significance. To solve these clinical problems, it is necessary to integrate clinical medicine and basic research. Bone regeneration after a fracture is an essential function of the living body. The prevailing view is that a small number of resident skeletal stem cells are solely responsible for regenerative capacity. Although these cells have long been considered to be in the bone marrow, it has been shown that they are also present in the growth plate and periosteum. More recently, distinct types of cells in the bone marrow, including bone marrow stromal cells, osteoblast progenitor cells, and osteoblasts, have been shown to participate in bone regeneration. Interestingly, the cellular plasticity of differentiated cells, rather than active recruitment of resident stem cell populations, may largely account for regeneration of bone tissues; terminally differentiated cells de\u2010differentiate into a stem cell\u2010like state, and then re\u2010differentiate into regenerating bone. In this review, we discuss the clinical risk and preventive therapy of bone fractures and the current concept of bone regeneration in basic mechanical insights, which may prove useful to both clinicians and researchers.<\/jats:p>","DOI":"10.1002\/ca.23917","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T21:43:52Z","timestamp":1654206232000},"page":"808-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bone regeneration: A message from clinical medicine and basic science"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-2828","authenticated-orcid":false,"given":"Yuta","family":"Tsukagoshi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-3249","authenticated-orcid":false,"given":"Yuki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504750102"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v7.i2.470"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00201-2"},{"key":"e_1_2_13_5_1","unstructured":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 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