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The main objective of our study was to determine breast skin thickness and breast skin and adipose\/fibroglandular tissue stiffness. The secondary objective was to assess clinical predictors of elasticity and thickness: age, smoking status, body mass index, contraception, pregnancies, breastfeeding, menopausal status, history of radiotherapy or breast surgery. Participants were included at the Montpellier University Breast Surgery Department from March to May 2022. Breast skin thickness was measured by ultrasonography, breast skin and adipose\/fibroglandular tissue stiffnesses were determined with a VLASTIC non\u2010invasive aspiration device at three different sites (breast segments I\u2013III). Multivariable linear models were used to assess clinical predictors of elasticity and thickness. In this cohort of 196 women, the mean breast skin and adipose\/fibroglandular tissue stiffness values were 39 and 3\u2009kPa, respectively. The mean breast skin thickness was 1.83\u2009mm. Only menopausal status was significantly correlated with breast skin thickness and adipose\/fibroglandular tissue stiffness. The next step will be to implement these stiffness and thickness values in a biomechanical breast model and to evaluate its capacity to predict breast tissue deformations.<\/jats:p>","DOI":"10.1002\/ca.24134","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T10:14:42Z","timestamp":1704363282000},"page":"329-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of breast skin and tissue stiffness using a non\u2010invasive aspiration device and impact of clinical predictors"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-7927","authenticated-orcid":false,"given":"Martha","family":"Duraes","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Montpellier University Hospital  Montpellier France"},{"name":"Faculty of Medicine Montpellier\u2010N\u00eemes, Laboratory of Anatomy of Montpellier Montpellier University  Montpellier France"},{"name":"Research\u2010Team ICAR, LIRMM University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemie","family":"Briot","sequence":"additional","affiliation":[{"name":"Univ. 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