{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:36:23Z","timestamp":1790325383344,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","award":["LIDER\/7\/0027\/L\u201010\/18\/NCBR\/2019"],"award-info":[{"award-number":["LIDER\/7\/0027\/L\u201010\/18\/NCBR\/2019"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The complex anatomy of the aortic root is of great importance for many surgical and transcatheter cardiac procedures. Therefore, the aim of this study was to provide a comprehensive morphological description of the nondiseased aortic root. We morphometrically examined 200 autopsied human adult hearts (22.0% females, 47.9\u2009\u00b1\u200917.7\u2009years). A meticulous macroscopic analysis of aortic root anatomy was performed. The largest cross\u2010section area of the aortic root was observed in coaptation center plane (653.9\u2009\u00b1\u2009196.5\u2009mm<jats:sup>2<\/jats:sup>), followed by tubular plane (427.7\u2009\u00b1 168.0\u2009mm<jats:sup>2<\/jats:sup>) and basal ring (362.7\u2009\u00b1\u2009159.1\u2009mm<jats:sup>2<\/jats:sup>) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The right coronary sinus was the largest (area: 234.3\u2009\u00b1\u200985.0\u2009mm<jats:sup>2<\/jats:sup>), followed by noncoronary sinus (218.7\u2009\u00b1\u200974.8\u2009mm<jats:sup>2<\/jats:sup>) and left coronary sinus (201.2\u2009\u00b1\u200978.08\u2009mm<jats:sup>2<\/jats:sup>). The noncoronary sinus was the deepest, followed by right and left coronary sinus (16.4\u2009\u00b1\u20093.2 vs. 15.9\u2009\u00b1\u20093.1 vs. 14.9\u2009\u00b1\u20092.9\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In 68.5% of hearts, the coaptation center was located near the aortic geometric center. The left coronary ostium was located 15.6\u2009\u00b1\u20093.8\u2009mm above sinus bottom (within the sinus in 91.5% and above sinutubular junction in 8.5%), while for right coronary ostium, it was 16.2\u2009\u00b1\u20093.5\u2009mm above (83.5% within sinus and 16.5% above). In general, males exhibited larger aortic valve dimensions than females. A multiple forward stepwise regression model showed that anthropometric variables might predict the size of coaptation center plane (age, sex, and heart weight; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200931.8%), tubular plane (age and sex; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200925.6%), and basal ring (age and sex; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200916.9%). In conclusion, this study presents a comprehensive analysis of aortic\u2010root morphometry and provides a platform for further research into the intricate interplay between structure and function of the aortic root.<\/jats:p>","DOI":"10.1002\/ca.24165","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T14:31:01Z","timestamp":1713364261000},"page":"719-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aortic root morphometry revisited\u2014Clinical implications for aortic valve interventions"],"prefix":"10.1002","volume":"37","author":[{"given":"Damian","family":"Dudkiewicz","sequence":"first","affiliation":[{"name":"HEART \u2010 Heart Embryology and Anatomy Research Team, Department of Anatomy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Lis","sequence":"additional","affiliation":[{"name":"HEART \u2010 Heart Embryology and Anatomy Research Team, Department of Anatomy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Yakovliev","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics Polish Academy of Sciences  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Ho\u0142da","sequence":"additional","affiliation":[{"name":"HEART \u2010 Heart Embryology and Anatomy Research Team, Department of Anatomy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Bolecha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Strona","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Kopacz","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-594X","authenticated-orcid":false,"given":"Mateusz K.","family":"Ho\u0142da","sequence":"additional","affiliation":[{"name":"HEART \u2010 Heart Embryology and Anatomy Research Team, Department of Anatomy Jagiellonian University Medical College  Cracow Poland"},{"name":"Division of Cardiovascular Sciences The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.670"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/HEARTJNL-2023-322716"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0967-2109(02)00018-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CPCARDIOL.2021.100957"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70092-4"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"407","article-title":"Aortic root geometry: Pattern of differences between leaflets and sinuses of Valsalva","volume":"8","author":"Choo S. 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