{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:46:08Z","timestamp":1792025168001,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK132346"],"award-info":[{"award-number":["R01 DK132346"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreas shape features, derived from 3D segmentation of the pancreas, might be relevant to identifying subtle disease\u2010related changes in the pancreas. This work utilized a retrospective sample of clinical contrast\u2010enhanced CT examinations of 140 children &lt;\u200918\u2009years of age. Manual segmentations of the pancreas were used to extract radiomic shape features and perform statistical shape modeling using a partial least squares regression approach. Age, weight, height, body surface area, and body mass index each showed significant associations with volume, surface area, surface area to volume ratio, compactness, major axis length, minor axis length, least axis length, and area density. Elastic net regression models showed that demographic variables had strong predictive power (cross\u2010validated\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    0.71\u20130.89) for pancreas volume, surface area, surface area to volume ratio, major axis length, minor axis length, and least axis length. In the analysis of shape modes, only the first partial least squares regression component accounted for a statistically significant amount of the demographic variance among participants (24.8% variance explained,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with significant loadings for age (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), weight (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), and height (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Our results are the first to characterize pancreas shape features in children with healthy pancreatic function and set the stage for future studies to understand how disease impacts pancreas shape, beyond global changes in volume, and how changes in shape might be used to diagnose and monitor disease.\n                  <\/jats:p>","DOI":"10.1002\/ca.70003","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:29:24Z","timestamp":1751675364000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of Healthy Pancreas Morphology Throughout Childhood"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-9568","authenticated-orcid":false,"given":"Jonathan A.","family":"Dudley","sequence":"first","affiliation":[{"name":"Imaging Research Center, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle E.","family":"Murdock","sequence":"additional","affiliation":[{"name":"Imaging Research Center, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu\u2010El\u2010Haija","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics College of Medicine, University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"378","article-title":"Computed Tomography\u2010Based Measurements of Normative Liver and Spleen Volumes in Children","volume":"53","author":"Padua V.","year":"2023","journal-title":"Pediatric Radiology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23217"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06126-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_7_6_1","unstructured":"Flint B. andC. A.Hall.2020.\u201cBody Surface Area.\u201d"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.10.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PG9.0000000000000337"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47686-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02590788"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824f1516"},{"issue":"3","key":"e_1_2_7_12_1","first-page":"69","article-title":"A Guide to Appropriate Use of Correlation Coefficient in Medical Research","volume":"24","author":"Mukaka M. 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S.Leger M.Valli\u00e8res andS.L\u00f6ck.2016.\u201cImage Biomarker Standardisation Initiative.\u201d arXiv Preprint arXiv:1612.07003."}],"container-title":["Clinical Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.70003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ca.70003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ca.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:58:28Z","timestamp":1773010708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ca.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ca.70003"],"URL":"https:\/\/doi.org\/10.1002\/ca.70003","archive":["Portico"],"relation":{},"ISSN":["0897-3806","1098-2353"],"issn-type":[{"value":"0897-3806","type":"print"},{"value":"1098-2353","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}