{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:03:11Z","timestamp":1780642991515,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Femoral nerve block is an essential regional anesthetic technique for surgery and analgesia of the anterior thigh, hip, and knee. Its effectiveness depends on understanding the femoral nerve's origin, branching pattern, fascial relationships, and common anatomical variations. This review summarizes current anatomical, cadaveric, and imaging studies to clarify the course of the femoral nerve and highlight variations such as high divisions, accessory branches, and vascular overlap that may influence block success. Approaches including landmark, nerve stimulator, and ultrasound\u2010guided techniques are reviewed with emphasis on procedural anatomy. Ultrasound features of the femoral nerve and fascia iliaca are correlated with cadaveric findings to outline optimal needle placement and spread of injectate. Continuous catheter methods, anesthetic selection, and volume considerations are also described. Comparative evidence indicates that ultrasound guidance improves accuracy, reduces vascular puncture, and decreases local anesthetic requirements compared with blind or stimulator\u2010based approaches. Clinical applications across orthopedic surgery, trauma care, and multimodal perioperative pathways are discussed, along with potential complications such as nerve injury, hematoma, systemic toxicity, and quadriceps weakness. Specifically, detailed knowledge of the femoral nerve's course beneath the fascia iliaca, its shifting proximity to the femoral vessels, and its variable early branching is the key to accurate needle placement, dependable block success, and fewer procedure\u2010related complications.<\/jats:p>","DOI":"10.1002\/ca.70152","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:42:02Z","timestamp":1780641722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Femoral Nerve Block: A Review of the Relevant Applied Anatomy, Anatomical Variations, and Procedural Considerations"],"prefix":"10.1002","author":[{"given":"Yuqian","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences St. George's University, School of Medicine  Grenada West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-2461","authenticated-orcid":false,"given":"Michael J.","family":"Montalbano","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences St. George's University, School of Medicine  Grenada West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewarld","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Pathology St. George's University, School of Medicine  Grenada West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-6657","authenticated-orcid":false,"given":"Marios","family":"Loukas","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences St. George's University, School of Medicine  Grenada West Indies"},{"name":"Department of Pathology St. George's University, School of Medicine  Grenada West Indies"},{"name":"Department of Clinical Anatomy Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/106698109791352201"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7860\/ijars\/2021\/47110.2613"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"1","article-title":"Anatomical Variations in Formation and Branching Pattern of the Femoral Nerve in the Iliac Fossa","volume":"4","author":"Astik R. 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