{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:14:10Z","timestamp":1790730850162,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Anatomy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Generative artificial intelligence (GAI) is increasingly being applied in biomedical sciences and medical education, including anatomy, where text\u2010to\u2010image generators may facilitate rapid creation of visual materials. However, the anatomical accuracy of such generated illustrations remains uncertain. The present study evaluated the performance of selected GAI models in generating anatomically correct representations of human anatomical structures. Six text\u2010to\u2010image generators (DALL\u2010E, Gemini, Freepik, Midjourney, DeepAI, and Canva) were assessed using a standardized prompt (\u201cGenerate the most anatomically accurate image of the human [name of anatomical structure]\u201d). For each anatomical region, two images were generated. The evaluated structures included the liver, femur, scapula, aortic arch, arm muscles, sacrum, humerus, thigh muscles, celiac trunk, kidney, brainstem, and lumbar plexus. All images were analyzed using reference tables based on Terminologia Anatomica, with individual structures assessed for presence and physiological correctness by four independent reviewers. Statistical analysis included calculation of structure\u2010level proportions with 95% confidence intervals, pairwise inter\u2010rater agreement using Cohen's\n                    <jats:italic>\u03ba<\/jats:italic>\n                    , and exploratory logistic regression with robust standard errors clustered by generated image to evaluate the effects of model, anatomical region, and evaluator. A total of 144 images were analyzed. DALL\u2010E demonstrated the highest overall proportion of structure\u2010level entries scored as present (56.7%, 95% CI: 53.8\u201359.5) as well as the highest proportion of physiologically correct entries among those present (66.0%, 95% CI: 62.2\u201369.5). When both criteria were combined, the proportion of fully correct structure\u2010level entries remained limited across all models, with the highest value observed for DALL\u2010E (37.4%). Considerable variability in performance was noted across anatomical regions, with particularly low accuracy observed for complex structures such as the lumbar plexus and celiac trunk. Inter\u2010rater agreement ranged from moderate to almost perfect. Overall, current GAI models demonstrate substantial limitations in producing anatomically accurate illustrations. Although certain models outperform others, the reliability of generated images remains insufficient, and expert verification is necessary before their application in medical education or scientific contexts.\n                  <\/jats:p>","DOI":"10.1002\/ca.70189","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:16:09Z","timestamp":1784614569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Generative Artificial Intelligence Models in Producing Anatomically Accurate Illustrations: A Comparative Study of Text\u2010to\u2010Image Generators"],"prefix":"10.1002","author":[{"given":"Aleksandra","family":"Struga\u0142a","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Applied Sciences  Tarn\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Batkowski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Applied Sciences  Tarn\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Skrzypo\u0144","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Applied Sciences  Tarn\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Mordarski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Paniec","sequence":"additional","affiliation":[{"name":"AGH University of Science and Technology  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Chaba\u2010Karna\u015b","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kozio\u0142","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Czele\u0144","sequence":"additional","affiliation":[{"name":"AGH University of Science and Technology  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6109-453X","authenticated-orcid":false,"given":"Grzegorz","family":"Fibiger","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"},{"name":"International Evidence\u2010Based Anatomy Working Group  Krak\u00f3w Poland"},{"name":"ARTROMED Orthopedic and Rehabilitation Center  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Mo\u017cd\u017ce\u0144","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"},{"name":"International Evidence\u2010Based Anatomy Working Group  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Plutecki","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy A.","family":"Walocha","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"},{"name":"International Evidence\u2010Based Anatomy Working Group  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7207-9532","authenticated-orcid":false,"given":"Tomasz","family":"Kozio\u0142","sequence":"additional","affiliation":[{"name":"Department of Anatomy Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201077565\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v31i4.22"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453054.2025.2504491"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.70076"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2025.109039"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.70002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2016.02.010"},{"key":"e_1_2_8_9_1","volume-title":"Terminologia Anatomica. 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