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In the serum of T\u2010ALL patients, the activity of lactate dehydrogenase A (\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      ) is increased. We proposed that targeting\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      may be a potential strategy to improve T\u2010ALL outcomes. The current study was conducted to investigate the antileukemic effect of\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      gene\u2010targeting treatment on T\u2010ALL and the underlying molecular mechanism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Primary T\u2010ALL cell lines Jurkat and DU528 were treated with the\n                      <jats:italic toggle=\"yes\">LDH<\/jats:italic>\n                      inhibitor oxamate. MTT, colony formation, apoptosis, and cell cycle assays were performed to investigate the effects of oxamate on T\u2010ALL cells. Quantitative real\u2010time PCR (qPCR) and Western blotting analyses were applied to determine the related signaling pathways. A mitochondrial reactive oxygen species (\n                      <jats:italic toggle=\"yes\">ROS<\/jats:italic>\n                      ) assay was performed to evaluate\n                      <jats:italic toggle=\"yes\">ROS<\/jats:italic>\n                      production after T\u2010ALL cells were treated with oxamate. A T\u2010ALL transgenic zebrafish model with\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      gene knockdown was established using CRISPR\/Cas9 gene\u2010editing technology, and then TUNEL, Western blotting, and T\u2010ALL tumor progression analyses were conducted to investigate the effects of\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      gene knockdown on T\u2010ALL transgenic zebrafish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells. It also arrested Jurkat and DU528 cells in G0\/G1 phase and stimulated\n                      <jats:italic toggle=\"yes\">ROS<\/jats:italic>\n                      production (all\n                      <jats:italic toggle=\"yes\">P\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Blocking\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      significantly decreased the gene and protein expression of\n                      <jats:italic toggle=\"yes\">c\u2010Myc<\/jats:italic>\n                      , as well as the levels of phosphorylated serine\/threonine kinase (AKT) and glycogen synthase kinase 3 beta (GSK\u20103\u03b2) in the phosphatidylinositol 3\u2032\u2010kinase (PI3K) signaling pathway.\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      gene knockdown delayed disease progression and down\u2010regulated\n                      <jats:italic toggle=\"yes\">c\u2010Myc<\/jats:italic>\n                      mRNA and protein expression in T\u2010ALL transgenic zebrafish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Targeting\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      exerted an antileukemic effect on T\u2010ALL, representing a potential strategy for T\u2010ALL treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cac2.12080","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T08:07:16Z","timestamp":1597997236000},"page":"501-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Targeting lactate dehydrogenase A (\n                    <i>LDHA<\/i>\n                    ) exerts antileukemic effects on T\u2010cell acute lymphoblastic leukemia"],"prefix":"10.34133","volume":"40","author":[{"given":"Haizhi","family":"Yu","sequence":"first","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Guizhou Provincial People's Hospital","place":["Guiyang, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Yin","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Xiangtan Central Hospital","place":["Xiangtan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Yi","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"the First Affiliated Hospital of Hunan Normal University","place":["Changsha, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Kuang","sequence":"additional","affiliation":[{"name":"Hunan Children's Hospital","place":["Changsha, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Li","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Zhong","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, P. R. China"]},{"name":"Central South University","place":["Changsha, P. R. 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Potential selective effect in T\u2010cell leukemia[J]","volume":"60","author":"Lauer SJ","year":"1987","unstructured":"Lauer SJ, Pinkel D, Buchanan GR, Sartain P, Cornet JM, Krance R, et\u00a0al. Cytosine arabinoside\/cyclophosphamide pulses during continuation therapy for childhood acute lymphoblastic leukemia. Potential selective effect in T\u2010cell leukemia[J]. Cancer 1987;60((10)):2366\u201071.","journal-title":"Cancer"},{"issue":"22","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/blood.V114.22.324.324","article-title":"Successful Subtype Oriented Treatment Strategies in Adult T\u2010All; Results of 744 Patients Treated in Three Consecutive GMALL Studies[J]","volume":"114","author":"Hoelzer D","year":"2009","unstructured":"Hoelzer D, Thiel E, Arnold R, Beck J, Beelen DW, Bornhauser M, et\u00a0al. Successful Subtype Oriented Treatment Strategies in Adult T\u2010All; Results of 744 Patients Treated in Three Consecutive GMALL Studies[J]. Blood 2009;114((22)):137\u2010137.","journal-title":"Blood"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fped.2014.00054","article-title":"The challenge of targeting notch in hematologic malignancies[J]","volume":"2","author":"Hernandez Tejada FN","year":"2014","unstructured":"Hernandez Tejada FN, Galvez Silva JR, Zweidler\u2010McKay P A. The challenge of targeting notch in hematologic malignancies[J]. Front Pediatr. 2014;2:54.","journal-title":"Front Pediatr."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fonc.2014.00108","article-title":"Targeting the PI3K\/mTOR Pathway in Pediatric Hematologic Malignancies[J]","volume":"4","author":"Tasian SK","year":"2014","unstructured":"Tasian SK, Teachey DT, Rheingold SR. Targeting the PI3K\/mTOR Pathway in Pediatric Hematologic Malignancies[J]. 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Am J Transl Res. 2016;8((9)):3630\u20103644.","journal-title":"Am J Transl Res"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3955"},{"issue":"9","key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3324\/haematol.2016.146381","article-title":"The relevance of PTEN\u2010AKT in relation to NOTCH1\u2010directed treatment strategies in T\u2010cell acute lymphoblastic leukemia[J]","volume":"101","author":"Mendes RD","year":"2016","unstructured":"Mendes RD, Cante\u2010Barrett K, Pieters R, Meijerink JP. The relevance of PTEN\u2010AKT in relation to NOTCH1\u2010directed treatment strategies in T\u2010cell acute lymphoblastic leukemia[J]. Haematologica 2016;101((9)):1010\u20107.","journal-title":"Haematologica"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3215.269"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1501"},{"issue":"3","key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1365-2141.1996.00398.x","article-title":"Serum LDH value as a predictor of clinical outcome in acute myelogenous leukaemia of the elderly[J]","volume":"92","author":"Ferrara F","year":"1996","unstructured":"Ferrara F, Mirto S. Serum LDH value as a predictor of clinical outcome in acute myelogenous leukaemia of the elderly[J]. Br J Haematol. 1996;92((3)):627\u201031.","journal-title":"Br J Haematol"},{"issue":"1","key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1038\/s41598-017-06378-7","article-title":"Tumor LDH\u2010A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis[J]","volume":"7","author":"Dong T","year":"2017","unstructured":"Dong T, Liu Z, Xuan Q, Wang Z, Ma W, Zhang Q. Tumor LDH\u2010A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis[J]. Sci Rep. 2017;7((1)):6069.","journal-title":"Sci Rep"},{"issue":"7","key":"e_1_3_2_19_2","first-page":"660","article-title":"Correlation of serum lactic dehydrogenase activity with the clinical status of patients with cancer, lymphomas, and the leukemias[J]","volume":"17","author":"Bierman HR","year":"1957","unstructured":"Bierman HR, Hill BR, Reinhardt L, Emory E. 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Blood. 1980;56((3)):351\u20105.","journal-title":"Blood"},{"issue":"2","key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/mpo.2950120205","article-title":"Serum LDH values in childhood acute leukemias and non\u2010Hodgkin's lymphoma[J]","volume":"12","author":"Suarez CR","year":"1984","unstructured":"Suarez CR, Andreeff M, Miller DR. Serum LDH values in childhood acute leukemias and non\u2010Hodgkin's lymphoma[J]. Med Pediatr Oncol. 1984;12((2)):89\u201092.","journal-title":"Med Pediatr Oncol"},{"issue":"4","key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1182\/blood.V54.4.928.928","article-title":"Serum lactic dehydrogenase as a prognostic tool for non\u2010Hodgkin lymphomas[J]","volume":"54","author":"Ferraris A M","year":"1979","unstructured":"Ferraris A M, Giuntini P, Gaetani GF. Serum lactic dehydrogenase as a prognostic tool for non\u2010Hodgkin lymphomas[J]. Blood. 1979;54((4)):928\u201032.","journal-title":"Blood"},{"issue":"5","key":"e_1_3_2_23_2","first-page":"1143","article-title":"Inhibition by oxamate and by oxalate[J]","volume":"234","author":"Novoa WB","year":"1959","unstructured":"Novoa WB, Winer AD, Glaid AJ, Schwert GW. Lactic dehydrogenase V. Inhibition by oxamate and by oxalate[J]. J Biol Chem. 1959;234((5)):1143\u20108.","journal-title":"J Biol Chem"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2620"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119857"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2407"},{"issue":"1","key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2014.11.046","article-title":"Oxamate\u2010mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt\u2010mTOR signaling pathway[J]","volume":"358","author":"Zhao Z","year":"2015","unstructured":"Zhao Z, Han F, Yang S, Wu J, Zhan W. Oxamate\u2010mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt\u2010mTOR signaling pathway[J]. Cancer Lett. 2015;358((1)):17\u201026.","journal-title":"Cancer Lett"},{"key":"e_1_3_2_28_2","first-page":"2791","article-title":"The Role of Glycolysis in the Growth of Tumor Cells. Iv. The Basis of Glucose Toxicity in Oxamate\u2010Treated, Cultured Cells[J]","volume":"240","author":"Goldberg EB","year":"1965","unstructured":"Goldberg EB, Nitowsky HM, Colowick SP. The Role of Glycolysis in the Growth of Tumor Cells. Iv. The Basis of Glucose Toxicity in Oxamate\u2010Treated, Cultured Cells[J]. J Biol Chem. 1965;240:2791\u20106.","journal-title":"J Biol Chem"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.050"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408708102"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06625.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080280"},{"issue":"2","key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1097-0134(20010501)43:2<175::AID-PROT1029>3.0.CO;2-#","article-title":"Structural basis for altered activity of M\u2010 and H\u2010isozyme forms of human lactate dehydrogenase[J]","volume":"43","author":"Read JA","year":"2001","unstructured":"Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Structural basis for altered activity of M\u2010 and H\u2010isozyme forms of human lactate dehydrogenase[J]. Proteins 2001;43((2)):175\u201085.","journal-title":"Proteins"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.506"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32529"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.9.4967"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.13.6658"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.021"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"issue":"36","key":"e_1_3_2_40_2","first-page":"21021","article-title":"Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia\u2010inducible factor 1 and cAMP response elements[J]","volume":"270","author":"Firth JD","year":"1995","unstructured":"Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia\u2010inducible factor 1 and cAMP response elements[J]. J Biol Chem. 1995;270((36)):21021\u20107.","journal-title":"J Biol Chem"},{"issue":"6","key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ccr.2006.05.012","article-title":"Cancer's sweet tooth[J]","volume":"9","author":"Bui T","year":"2006","unstructured":"Bui T, Thompson CB. Cancer's sweet tooth[J]. Cancer Cell. 2006;9((6)):419\u201020.","journal-title":"Cancer Cell"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.6"},{"issue":"9","key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/1878-0261.12363","article-title":"PGC1beta regulates multiple myeloma tumor growth through LDHA\u2010mediated glycolytic metabolism[J]","volume":"12","author":"Zhang H","year":"2018","unstructured":"Zhang H, Li L, Chen Q, Li M, Feng J, Sun Y, et\u00a0al. 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Ai Zheng. 2009;28((2)):112\u20106.","journal-title":"Ai Zheng"},{"issue":"8","key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41419-018-0887-0","article-title":"PAK2\u2010c\u2010Myc\u2010PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect[J]","volume":"9","author":"Gupta A","year":"2018","unstructured":"Gupta A, Ajith A, Singh S, Panday RK, Samaiya A, Shukla S. PAK2\u2010c\u2010Myc\u2010PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect[J]. 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