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The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self\u2010renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self\u2010renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)\/\u03b2\u2010catenin, Notch, Hedgehog, nuclear factor kappa B (NF\u2010\u03baB), Janus kinase\/signal transducer and activator of transcription (JAK\/STAT), peroxisome proliferator\u2010activated receptor (PPAR), phosphatidyl\u2010inositol\u20103\u2010kinase\/Akt\/mechanistic target of rapamycin (PI3K\/Akt\/mTOR), and transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2)\/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC\u2010targeting drugs, and allowing better cure rates in anti\u2010CRC therapy.<\/jats:p>","DOI":"10.1002\/cac2.12235","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:55:20Z","timestamp":1637204120000},"page":"1275-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells"],"prefix":"10.34133","volume":"41","author":[{"given":"Valdenizia R.","family":"Silva","sequence":"first","affiliation":[{"name":"Oswaldo Cruz Foundation (IGM\u2010FIOCRUZ\/BA)","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano de S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation (IGM\u2010FIOCRUZ\/BA)","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane B.","family":"Dias","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation (IGM\u2010FIOCRUZ\/BA)","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio A.","family":"Quadros","sequence":"additional","affiliation":[{"name":"Rede D'Or\/S\u00e3o Luiz","place":["Salvador, Brazil"]},{"name":"Bahia State University","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-2063","authenticated-orcid":false,"given":"Daniel P.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation (IGM\u2010FIOCRUZ\/BA)","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2017.01.014"},{"issue":"1","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie YH","year":"2020","unstructured":"Xie YH, Chen YX, Fang JY. 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