{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:31:13Z","timestamp":1791811873816,"version":"4.3.4"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Research Fund of the Health Commission of Hubei Province","award":["WJ2021M255"],"award-info":[{"award-number":["WJ2021M255"]}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["SQ2019YFC200078\/02"],"award-info":[{"award-number":["SQ2019YFC200078\/02"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB184"],"award-info":[{"award-number":["2022CFB184"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Commun"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of glucose metabolism is critical in the development of HCC. The Warburg effect has recently been confirmed to occur in a variety of cancers, including HCC. However, little is known about the molecular biological mechanisms underlying the Warburg effect in HCC cells. In this study, we sought to better understand how methyltransferase 5, N6\u2010adenosine (METTL5) controls the development of HCC and the Warburg effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In the current study, quantitative real\u2010time polymerase chain reaction and Western blotting were used to detect the expression of METTL5 in HCC tissues and cell lines. Several different cell models and animal models were established to determine the role of METTL5 in glucose metabolism reprogramming and the underlying molecular mechanism of HCC. Glutathione\u2010S\u2010transferase pulldown, coimmunoprecipitation, RNA sequencing, non\u2010targeted metabolomics, polysome profiling, and luciferase reporter assays were performed to investigate the molecular mechanisms of METTL5 in HCC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We discovered that METTL5 drove glucose metabolic reprogramming to promote the proliferation and metastasis of HCC. Mechanistically, upregulation of METTL5 promoted c\u2010Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A (\n                      <jats:italic toggle=\"yes\">LDHA<\/jats:italic>\n                      ), enolase 1 (\n                      <jats:italic toggle=\"yes\">ENO1<\/jats:italic>\n                      ), triosephosphate isomerase 1 (\n                      <jats:italic toggle=\"yes\">TPI1<\/jats:italic>\n                      ), solute carrier family 2 member 1 (\n                      <jats:italic toggle=\"yes\">SLC2A1<\/jats:italic>\n                      ), and pyruvate kinase M2 (\n                      <jats:italic toggle=\"yes\">PKM2<\/jats:italic>\n                      ). The c\u2010Box and ubiquitin binding domain (UBA) regions of ubiquitin specific peptidase 5 (USP5) binded to c\u2010Myc protein and inhibited K48\u2010linked polyubiquitination of c\u2010Myc. Further study revealed that METTL5 controled the USP5 translation process, which in turn regulated the ubiquitination of c\u2010Myc. Furthermore, we identified cAMP responsive element binding protein 1 (CREB1)\/P300 as a critical transcriptional regulator of METTL5 that promoted the transcription of METTL5 in HCC. In patient\u2010derived tumor xenograft (PDX) models, adenovirus\u2010mediated knockout of METTL5 had a good antitumor effect and prolonged the survival of PDX\u2010bearing mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">These findings point to a novel mechanism by which CREB1\/P300\u2010METTL5\u2010USP5\u2010c\u2010Myc controls abnormal glucose metabolism and promotes tumor growth, suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cac2.12403","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T10:23:16Z","timestamp":1672914196000},"page":"338-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["METTL5 stabilizes c\u2010Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression"],"prefix":"10.34133","volume":"43","author":[{"given":"Peng","family":"Xia","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"The First Affiliated Hospital of Yangtze University","place":["Jingzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kequan","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shenzhen People's Hospital (The Second Clinical Medical College","place":["Shenzhen, P. R. China"]},{"name":"Jinan University","place":["Shenzhen, P. R. China"]},{"name":"The First Affiliated Hospital","place":["Shenzhen, P. R. China"]},{"name":"Southern University of Science and Technology)","place":["Shenzhen, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Gongye","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-3803","authenticated-orcid":false,"given":"Yufeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University","place":["Wuhan, P. R. China"]},{"name":"Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province","place":["Wuhan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"issue":"9399","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet JM","year":"2003","unstructured":"Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362((9399)):1907\u201017.","journal-title":"Lancet"},{"issue":"1","key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/hep.27388","article-title":"Emerging trends in hepatocellular carcinoma incidence and mortality","volume":"61","author":"Njei B","year":"2015","unstructured":"Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology. 2015;61((1)):191\u20109.","journal-title":"Hepatology"},{"issue":"2","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jhep.2019.08.025","article-title":"Epidemiology and surveillance for hepatocellular carcinoma: New trends","volume":"72","author":"Singal AG","year":"2020","unstructured":"Singal AG, Lampertico P, Nahon P. Epidemiology and surveillance for hepatocellular carcinoma: New trends. J Hepatol. 2020;72((2)):250\u201061.","journal-title":"J Hepatol"},{"issue":"1","key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-020-01629-4","article-title":"Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma","volume":"39","author":"Feng J","year":"2020","unstructured":"Feng J, Li J, Wu L, Yu Q, Ji J, Wu J, et\u00a0al. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2020;39((1)):126.","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.06.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","article-title":"Metabolic reprogramming: the emerging concept and associated therapeutic strategies","volume":"34","author":"Yoshida GJ","year":"2015","unstructured":"Yoshida GJ. Metabolic reprogramming: the emerging concept and associated therapeutic strategies. J Exp Clin Cancer Res. 2015;34:111.","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2018.03.001"},{"issue":"10","key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s12272-019-01185-2","article-title":"Warburg effect and its role in tumourigenesis","volume":"42","author":"Lebelo MT","year":"2019","unstructured":"Lebelo MT, Joubert AM, Visagie MH. Warburg effect and its role in tumourigenesis. Arch Pharm Res. 2019;42((10)):833\u201047.","journal-title":"Arch Pharm Res"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3038"},{"issue":"2","key":"e_1_3_2_12_2","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect","volume":"38","author":"San\u2010Millan I","year":"2017","unstructured":"San\u2010Millan I, Brooks GA. Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect. Carcinogenesis. 2017;38((2)):119\u201033.","journal-title":"Carcinogenesis"},{"issue":"1","key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12943-020-01172-y","article-title":"The emerging roles of N6\u2010methyladenosine (m6A) deregulation in liver carcinogenesis","volume":"19","author":"Chen M","year":"2020","unstructured":"Chen M, Wong CM. The emerging roles of N6\u2010methyladenosine (m6A) deregulation in liver carcinogenesis. Mol Cancer. 2020;19((1)):44.","journal-title":"Mol Cancer"},{"issue":"1","key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12943-019-1106-z","article-title":"KIAA1429 contributes to liver cancer progression through N6\u2010methyladenosine\u2010dependent post\u2010transcriptional modification of GATA3","volume":"18","author":"Lan T","year":"2019","unstructured":"Lan T, Li H, Zhang D, Xu L, Liu H, Hao X, et\u00a0al. KIAA1429 contributes to liver cancer progression through N6\u2010methyladenosine\u2010dependent post\u2010transcriptional modification of GATA3. Mol Cancer. 2019;18((1)):186.","journal-title":"Mol Cancer"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz619"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.333369.119"},{"issue":"10","key":"e_1_3_2_17_2","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949863","article-title":"The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation","volume":"21","author":"Xing M","year":"2020","unstructured":"Xing M, Liu Q, Mao C, Zeng H, Zhang X, Zhao S, et\u00a0al. The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation. EMBO Rep. 2020;21((10)):e49863.","journal-title":"EMBO Rep"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108544"},{"issue":"1","key":"e_1_3_2_19_2","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2021.5299","article-title":"Ribosome 18S m(6)A methyltransferase METTL5 promotes pancreatic cancer progression by modulating cMyc translation","volume":"60","author":"Huang H","year":"2022","unstructured":"Huang H, Li H, Pan R, Wang S, Khan AA, Zhao Y, et\u00a0al. Ribosome 18S m(6)A methyltransferase METTL5 promotes pancreatic cancer progression by modulating cMyc translation. Int J Oncol. 2022;60((1)).","journal-title":"Int J Oncol"},{"issue":"7","key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41419-021-03973-5","article-title":"MYC\u2010targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma","volume":"12","author":"Xia P","year":"2021","unstructured":"Xia P, Zhang H, Xu K, Jiang X, Gao M, Wang G, et\u00a0al. MYC\u2010targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma. Cell Death Dis. 2021;12((7)):691.","journal-title":"Cell Death Dis"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3543"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108597","article-title":"Lactic acid, a driver of tumor\u2010stroma interactions","volume":"106","author":"Niu D","year":"2022","unstructured":"Niu D, Wu Y, Lei Z, Zhang M, Xie Z, Tang S. Lactic acid, a driver of tumor\u2010stroma interactions. Int Immunopharmacol. 2022;106:108597.","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"e_1_3_2_23_2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082252","article-title":"Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer","volume":"12","author":"Varghese E","year":"2020","unstructured":"Varghese E, Samuel SM, Liskova A, Samec M, Kubatka P, Busselberg D. Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer. Cancers (Basel). 2020;12((8)).","journal-title":"Cancers (Basel)"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.189365.112"},{"issue":"3","key":"e_1_3_2_25_2","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi M","year":"2021","unstructured":"Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K. Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021;40((3)):e104705.","journal-title":"EMBO J"},{"issue":"2","key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41419-021-03466-5","article-title":"c\u2010MYC\u2010induced long noncoding RNA MEG3 aggravates kidney ischemia\u2010reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt\/beta\u2010catenin pathway","volume":"12","author":"Liu D","year":"2021","unstructured":"Liu D, Liu Y, Zheng X, Liu N. c\u2010MYC\u2010induced long noncoding RNA MEG3 aggravates kidney ischemia\u2010reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt\/beta\u2010catenin pathway. Cell Death Dis. 2021;12((2)):191.","journal-title":"Cell Death Dis"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.11.024"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00708-5"},{"issue":"3","key":"e_1_3_2_29_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014365","article-title":"MYC degradation","volume":"4","author":"Farrell AS","year":"2014","unstructured":"Farrell AS, Sears RC. MYC degradation. Cold Spring Harb Perspect Med. 2014;4((3)).","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41421-019-0136-4","article-title":"Human MettL3\u2010MettL14 complex is a sequence\u2010specific DNA adenine methyltransferase active on single\u2010strand and unpaired DNA in vitro","volume":"5","author":"Woodcock CB","year":"2019","unstructured":"Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, et\u00a0al. Human MettL3\u2010MettL14 complex is a sequence\u2010specific DNA adenine methyltransferase active on single\u2010strand and unpaired DNA in vitro. Cell Discov. 2019;5:63.","journal-title":"Cell Discov"},{"issue":"6","key":"e_1_3_2_31_2","doi-asserted-by":"crossref","DOI":"10.3892\/or.2021.8039","article-title":"CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma","volume":"45","author":"Wang Z","year":"2021","unstructured":"Wang Z, Zhang X, Tian X, Yang Y, Ma L, Wang J, et\u00a0al. CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Oncol Rep. 2021;45((6)).","journal-title":"Oncol Rep"},{"issue":"1","key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13045-019-0829-z","article-title":"Applications of patient\u2010derived tumor xenograft models and tumor organoids","volume":"13","author":"Yoshida GJ","year":"2020","unstructured":"Yoshida GJ. Applications of patient\u2010derived tumor xenograft models and tumor organoids. J Hematol Oncol. 2020;13((1)):4.","journal-title":"J Hematol Oncol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-152"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105937"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2231"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0889"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.679445","article-title":"Targeting the MYC Ubiquitination\u2010Proteasome Degradation Pathway for Cancer Therapy","volume":"11","author":"Sun XX","year":"2021","unstructured":"Sun XX, Li Y, Sears RC, Dai MS. Targeting the MYC Ubiquitination\u2010Proteasome Degradation Pathway for Cancer Therapy. Front Oncol. 2021;11:679445.","journal-title":"Front Oncol"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.748852","article-title":"Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy","volume":"12","author":"Zhou Y","year":"2021","unstructured":"Zhou Y, Gao X, Yuan M, Yang B, He Q, Cao J. Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy. Front Pharmacol. 2021;12:748852.","journal-title":"Front Pharmacol"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104557"},{"issue":"4","key":"e_1_3_2_41_2","article-title":"Stabilization of ERK\u2010Phosphorylated METTL3 by USP5 Increases m(6)A Methylation","volume":"80","author":"Sun HL","year":"2020","unstructured":"Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, et\u00a0al. Stabilization of ERK\u2010Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Mol Cell. 2020;80((4)):633\u201047 e7.","journal-title":"Mol Cell"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3389\/fphar.2020.00668","article-title":"USP5 Promotes Metastasis in Non\u2010Small Cell Lung Cancer by Inducing Epithelial\u2010Mesenchymal Transition via Wnt\/beta\u2010Catenin Pathway","volume":"11","author":"Xue S","year":"2020","unstructured":"Xue S, Wu W, Wang Z, Lu G, Sun J, Jin X, et\u00a0al. USP5 Promotes Metastasis in Non\u2010Small Cell Lung Cancer by Inducing Epithelial\u2010Mesenchymal Transition via Wnt\/beta\u2010Catenin Pathway. Front Pharmacol. 2020;11:668.","journal-title":"Front Pharmacol"}],"container-title":["Cancer Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cac2.12403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cac2.12403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1002\/cac2.12403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:49:41Z","timestamp":1773823781000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1002\/cac2.12403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/cac2.12403"],"URL":"https:\/\/doi.org\/10.1002\/cac2.12403","relation":{},"ISSN":["2523-3548"],"issn-type":[{"value":"2523-3548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"assertion":[{"value":"2022-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}