{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:14:09Z","timestamp":1792088049551,"version":"4.4.0"},"reference-count":165,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"10","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Communications"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this review, we revisit the pivotal role of fibroblast growth factor receptor 3 (FGFR3) in bladder cancer (BLCA), underscoring its prevalence in both non\u2010muscle\u2010invasive and muscle\u2010invasive forms of the disease. FGFR3 mutations in up to half of BLCAs play a well\u2010established role in tumorigenesis, shaping distinct tumor initiation patterns and impacting the tumor microenvironment (TME). Emphasizing the importance of considering epithelial\u2010mesenchymal transition profile and TME status, we revisit their relevance in predicting responses to immune checkpoint inhibitors in FGFR3\u2010mutated BLCAs. This writing highlights the initially promising yet transient efficacy of the FGFR inhibitor Erdafitinib on FGFR3\u2010mutated BLCA, stressing the pressing need to unravel resistance mechanisms and identify co\u2010targets for future combinatorial studies. A thorough analysis of recent preclinical and clinical evidence reveals resistance mechanisms, including secondary mutations, epigenetic alterations in pathway effectors, phenotypic heterogeneity, and population\u2010specific variations within FGFR3 mutational status. Lastly, we discuss the potential of combinatorial treatments and concepts like synthetic lethality for discovering more effective targeted therapies against FGFR3\u2010mutated BLCA.<\/jats:p>","DOI":"10.1002\/cac2.12602","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T02:44:40Z","timestamp":1724121880000},"page":"1189-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["<i>FGFR3<\/i>\n                    alterations in bladder cancer: Sensitivity and resistance to targeted therapies"],"prefix":"10.34133","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-5630","authenticated-orcid":false,"given":"Maxim","family":"Noeraparast","sequence":"first","affiliation":[{"name":"Translational Oncology II. Med Clinics Hematology and Oncology  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Krajina","sequence":"additional","affiliation":[{"name":"Translational Oncology II. Med Clinics Hematology and Oncology  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Pichler","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Nieders\u00fc\u00df\u2010Beke","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Clinics Ottakring  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Gr\u00fcnwald","sequence":"additional","affiliation":[{"name":"Interdisciplinary Genitourinary Oncology Clinic for Urology, Clinic for Medical Oncology University Hospital Essen, Hufelandstra\u00dfe 55  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Ahyai","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pichler","sequence":"additional","affiliation":[{"name":"Translational Oncology II. Med Clinics Hematology and Oncology  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010020\u201000313\u20101"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000468\u20109"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102530"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Can bladder cancer be found early?","author":"The American Cancer Society medical and editorial content team","year":"2016","journal-title":"Am Cancer Soc"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3800"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/12615"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi290"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210399"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds486"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12965"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.006"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201018\u20100229"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817323"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120605109"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.05.004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001897\u20106"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2798"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168\u20109525(97)01131\u20101"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0696\u2010233"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.10.21.23297089"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.032"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20101283"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.280"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2207"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.09.030"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.006874"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u201001157\u20100"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u201000222\u20107"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101204"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00660\u20104"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.46883\/2023.25920999"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00275\u20109"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308849"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.3116"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.003"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.003"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.3116"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.110"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122968"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.794"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002934\u20107"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010023\u201000439\u20101"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20102646"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad149"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.110"},{"key":"e_1_2_12_48_1","volume-title":"Hyperphosphatemia","author":"Goyal R","year":"2024"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30109\u20101"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20103334"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12727"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201005\u20100282"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz249.016"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.4547"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.4534"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38017"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30357"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3523756"},{"key":"e_1_2_12_60_1","doi-asserted-by":"crossref","unstructured":"KarlK Del PiccoloN LightT RoyT DudejaP UrsachiV\u2010C et\u00a0al.Ligand bias underlies differential signaling of multiple FGFs via FGFR1 2023.https:\/\/doi.org\/10.7554\/elife.88144.2","DOI":"10.7554\/eLife.88144.3"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133465"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10262"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102832"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010015\u20109579\u20108"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.8"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt419"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201010\u20100168"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101603"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20103212"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20102329"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010018\u20100115\u2010y"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14109"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.02.018"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u20104\u201015"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.08.020"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158675"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V130.Suppl_1.3027.3027"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100250"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060540"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2020.00006"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33392"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002167"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203175"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800837"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700422"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1091551"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20101891\u20103\u201039"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990611)84:5<476::AID-AJMG12>3.0.CO;2-X"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1086\/316892"},{"key":"e_1_2_12_90_1","first-page":"368","article-title":"Achondroplasia is defined by recurrent G380R mutations of FGFR3","volume":"56","author":"Bellus GA","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450033490993"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101859200"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21636"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010020\u20100469\u20102"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy031"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx374"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.12.1255"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6690"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.730093"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.09.026"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2008.10.008"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45286"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1086\/508433"},{"key":"e_1_2_12_104_1","first-page":"4049","article-title":"Novel Transcripts of Fibroblast Growth Factor Receptor 3 Reveal Aberrant Splicing and Activation of Cryptic Splice Sequences in Colorectal Cancer1","volume":"60","author":"Jang J\u2010H","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25941"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003089\u20102"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u201012\u201083"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.860985"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9050052"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101618"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.05.010"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.017160"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.5.681"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.2043"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006961"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201004994\u20104"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33404"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6585"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.11.010"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E23\u201002\u20100058"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.18.4139"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33718"},{"key":"e_1_2_12_123_1","unstructured":"GironP EggermontC NoeparastA TeugelsE GutierrezG De Gr\u00e8veJ.The deubiquitinase USP13 as a novel therapeutic co\u2010target in EGFR mutant non\u2010small cell lung cancer 2018."},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708163"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009478\u20104"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201023\u20101398"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201012\u20100569"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.01.021"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000001177"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061416"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010021\u201001488\u20106"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005992\u2010x"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201023\u20101065"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI169241"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201021\u20102362"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201018\u20100277"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u20100801\u20107"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102022\u2010006643"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201037568\u20109"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.106976"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.06.025"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201247R"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6034"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201022\u20101441"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010023\u201000417\u20105"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.930731"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2018.05.001"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.526"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13124"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00104"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010020\u20100262\u20101"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz067"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3649"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.012"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005408\u20101"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1254906"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010023\u201001461\u2010x"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.4_suppl.625"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3297"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.4-5-426"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010018\u20100171\u2010x"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201008\u20102904"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.06.004"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201020\u20101187"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4369"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm99"}],"container-title":["Cancer Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cac2.12602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:54:31Z","timestamp":1767786871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cac2.12602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":165,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/cac2.12602"],"URL":"https:\/\/doi.org\/10.1002\/cac2.12602","archive":["Portico"],"relation":{},"ISSN":["2523-3548","2523-3548"],"issn-type":[{"value":"2523-3548","type":"print"},{"value":"2523-3548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"2024-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}