{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:55:09Z","timestamp":1791600909840,"version":"4.3.4"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"11","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01KD2104A"],"award-info":[{"award-number":["01KD2104A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Commun"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early\u2010onset CRC (EOCRC) risk and family history of both colorectal carcinomas and polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a nationwide cohort study leveraging Swedish family\u2010cancer datasets with follow\u2010up from 1964 to 2018. Standardized incidence ratios (SIRs) were calculated to estimate the risk of CRC and EOCRC among individuals with a family history of both colorectal polyps and carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We followed up 13,432,205 individuals for up to 54 years. The risk of overall CRC was 2.2 times increased in individuals with 1 first\u2010degree relative (FDR) with one\u2010time polyp diagnosis and an additional FDR with carcinoma (95% CI = 2.1\u20102.3; EOCRC SIR = 2.9 [95% CI = 2.4\u20103.4]). The risk was significantly higher in individuals with 1 FDR with repeated polyp diagnoses (\u22652 times) and an additional FDR with carcinoma (overall SIR = 2.9 [95% CI = 2.7\u20103.1]; EOCRC SIR = 5.4 [95% CI = 3.9\u20106.4]). A similar risk was observed in individuals with \u22652 FDRs with one\u2010time polyp diagnosis and an additional FDR with carcinoma (overall SIR = 2.9 [95% CI = 2.4\u20103.4]; EOCRC SIR = 5.3 [95% CI = 3.0\u20108.6]). Individuals with \u22652 FDRs with repeated polyp diagnoses and an additional FDR with carcinoma had a 5.0\u2010fold overall risk (95% CI = 4.3\u20105.7) and a 13.8\u2010fold EOCRC risk (95% CI = 9.7\u201020.1). Younger age at polyp\/carcinoma diagnoses, and more relatives with polyps and carcinomas were associated with higher CRC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Individuals with a family history of both colorectal polyps and carcinomas are at significantly increased risk of CRC, especially EOCRC. The risk increased with frequent polyp diagnoses, younger age at first polyp\/carcinoma diagnoses, and the number of relatives with polyps\/carcinomas. This study highlights the importance of considering both colorectal polyps and carcinomas in family history when assessing CRC risk. These findings could supplement current screening guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cac2.70059","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T03:34:38Z","timestamp":1756870478000},"page":"1407-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study"],"prefix":"10.34133","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2271","authenticated-orcid":false,"given":"Yuqing","family":"Hu","sequence":"first","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Kharazmi","sequence":"additional","affiliation":[{"name":"Lund University","place":["Malmo, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunfeng","family":"Liang","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Heidelberg, Germany"]},{"name":"Heidelberg University","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Lund University","place":["Malmo, Sweden"]},{"name":"University Clinic Primary Care","place":["Region Skane, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Lund University","place":["Malmo, Sweden"]},{"name":"University Clinic Primary Care","place":["Region Skane, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Fallah","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Heidelberg, Germany"]},{"name":"Lund University","place":["Malmo, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"issue":"2","key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cac2.12627","article-title":"Cancer situation in China: an analysis based on the global epidemiological data released in 2024","volume":"45","author":"Diao X","year":"2025","unstructured":"Diao X, Guo C, Jin Y, Li B, Gao X, Du X, et\u00a0al. 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