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In recent years, targeting non\u2010apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to their ability to release damage\u2010associated molecular patterns (DAMPs), enhance antigen presentation, and remodel the tumor immune microenvironment, thereby activating anti\u2010tumor immune responses. A number of studies have shown that precise induction of these pathways by small molecules or nanoparticles can reverse the resistance to chemoradiotherapy and ICIs, promote the transformation of \u201ccold tumors\u201d to \u201chot tumors,\u201d and ultimately establish durable immune memory. This article systematically reviewed the key mechanisms and immunomodulatory functions of five types of non\u2010apoptotic RCD (ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis), discussed the related treatment strategies, and prospects for the future application in combination with existing immunotherapy.<\/jats:p>","DOI":"10.1002\/cac2.70064","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:50:30Z","timestamp":1758873030000},"page":"1456-1495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mechanism and role of regulated cell death in tumor immunity and immunotherapy"],"prefix":"10.34133","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8813-1846","authenticated-orcid":false,"given":"Jingwen","family":"Hu","sequence":"first","affiliation":[{"name":"Xiangya Hospital","place":["Changsha, P. R. 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