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So, considering the current situation, phytochemicals could be a viable option for developing chemotherapeutic agents for managing numerous types of malignancies. Therefore, we aimed to locate all phytochemicals of\n                    <jats:italic>Eclipta prostrata<\/jats:italic>\n                    and unravel their chemotherapeutic mechanisms and strategies individually. We defined 25 active compounds based on their anticancer activities after filtering through IMPPAT and literature search, and these compounds have chemotherapeutic activities against around 15 different human malignancies. In vitro and preclinical models support that the chemotherapeutic properties of phytochemicals derived from\n                    <jats:italic>Eclipta prostrata<\/jats:italic>\n                    are believed to be regulated by many pathways, including targeting signaling pathways, for example, phosphoinositide 3\u2010kinase (PI3K)\/AKT\/mammalian target of rapamycin (mTOR), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), nuclear Factor\u2010kappa B (NF\u2010\u03baB), mitogen\u2010activated protein kinase (MAPK); regulated cell death such as Fas cell surface death receptor (FAS), Bid, apoptosis\u2010inducing factor (AIF), Bcl2, Bax, Bak, Bad, caspase, and Poly (ADP\u2010ribose) Polymerase (PARP); metastasis and angiogenesis such as matrix metalloproteinases (MMPs) (2&amp;9), wingless\/integrated (Wnt)\/beta\u2010catenin, angiogenesis (E\u2010cCadherin &amp; N\u2010cadherin, vimentin), cell proliferation (cyclins\u2010A, B1, D1, E1, and cyclin\u2010dependent kinases (CDKs) 1, 2,4), inflammatory molecules (programmed death\u2010ligand 1 (PD\u2010L1), TNF\u2010\u03b1, NF\u2010\u03baB, Interleukin\u20101 (IL\u20101), Interleukin\u20106 (IL\u20106), Interleukin\u20108 (IL\u20108), Interleukin\u20101 beta (IL\u20101\u03b2)), regulating tumor suppressor genes (p21, p27, p38, p51, p53), microRNA (miRNA) regulation, and some nonspecific pathways like DNA fragmentation damage and repair, autophagy (light chain 3\u2010II (LC3\u2010II) and mTOR), and many other pathways. Some selective phytochemicals exert synergistic activities with standard chemotherapeutic drugs and reverse drug resistance through several mechanisms. Nano\u2010based phytochemicals target numerous cancer cells, resulting in drug accumulation and improved drug efficacy, making phytochemicals more potent chemotherapeutic agents in cancer treatment. Additionally, an in\u2010silico pharmacokinetics study reveals that phytoestrogen possesses suitable pharmacokinetic characteristics with minor toxicity in the human body. So, direct consumption of different parts of\n                    <jats:italic>Eclipta prostrata<\/jats:italic>\n                    or specific phytochemicals from this plant can be a potential candidate drug against human malignancies.\n                  <\/jats:p>","DOI":"10.1002\/cai2.70038","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T05:51:31Z","timestamp":1766382691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening the Active Phytochemicals From\n                    <i>Eclipta prostrata<\/i>\n                    and Unraveling Their Molecular Insight Into Human Malignancies"],"prefix":"10.1002","volume":"4","author":[{"given":"Md. Sakhawat","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Santosh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanzida","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Primeasia University Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Mojnu","family":"Mia","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Santosh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatematuz","family":"Zohora","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy University of Dhaka Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Rifat","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University Santosh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Tanjida Islam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Santosh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Abu","family":"Sayeed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals Science St John's University Queens New York City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moushumi Afroza","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Biological Science St John's University Queens New York City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-4029","authenticated-orcid":false,"given":"Sherif","family":"Hamidu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Noguchi Memorial Institute for Medical Research University of Ghana Accra Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Hamidu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine International University of Africa Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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