{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:31:44Z","timestamp":1772998304790,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404340"],"award-info":[{"award-number":["82404340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273722"],"award-info":[{"award-number":["82273722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373685"],"award-info":[{"award-number":["82373685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204143"],"award-info":[{"award-number":["82204143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Innovation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune\u2010mediated inflammatory disease (IMID) and cancer share underlying mechanisms. We aimed to comprehensively evaluate the associations between IMIDs and cancers from global, population and genetic perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A triangulation framework was employed to assess the association between IMIDs and cancers, using the Global Burden of Disease Study (2012\u20132021) to analyse six IMIDs and 33 cancers. The UK Biobank (UKBB) prospective cohort was subsequently used to validate these associations, with hazard ratios (HRs) and 95% confidence intervals (CIs) estimated by Cox proportional hazards models. Causal inference based on genetic instruments was performed in the FinnGen and UKBB to assess the potential causal effects between IMIDs and cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IMIDs were positively associated with the occurrence of cancers from a global perspective. Moreover, 170 specific IMID\u2010cancer pairs revealed statistically significant associations. A total of 20 pairs of specific IMID\u2010cancer associations were further confirmed in the UKBB cohort. Among these, the five most pronounced associations included atopic dermatitis with Hodgkin lymphoma (HR\u2009=\u200912.56, 95% CI: 1.76\u201389.59), with ovarian cancer (HR\u2009=\u20095.65, 95% CI: 1.41\u201322.65) and with non\u2010Hodgkin lymphoma (HR\u2009=\u20095.11, 95% CI: 1.91\u201313.63); rheumatoid arthritis with Hodgkin lymphoma (HR\u2009=\u20093.85, 95% CI: 1.11\u201313.32); and psoriasis with Hodgkin lymphoma (HR\u2009=\u20093.43, 95% CI: 1.69\u20136.96). Additionally, a positive causal association between rheumatoid arthritis and Hodgkin lymphoma (inverse variance weighted OR\u2009=\u20091.31, 95% CI: 1.10\u20131.57) was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides comprehensive evidence of the relationships between IMIDs and cancers from global, population and genetic perspectives and identifies 20 pairs of specific IMID\u2010cancer associations, thereby contributing to advancements in cancer prevention and control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cai2.70048","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:48:08Z","timestamp":1768880888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global, Population and Genetic Evidence on the Relationships Between Immune\u2010Mediated Inflammatory Disease and Cancer Risk"],"prefix":"10.1002","volume":"5","author":[{"given":"Xuesi","family":"Dong","sequence":"first","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilin","family":"Luo","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health Nanjing Medical University Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing Jiangsu China"},{"name":"Changzhou Institute for Advanced Study of Public Health Nanjing Medical University Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenran","family":"Wang","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Shi","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeming","family":"Guo","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Chen","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sipeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health Nanjing Medical University Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing Jiangsu China"},{"name":"Changzhou Institute for Advanced Study of Public Health Nanjing Medical University Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengwei","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-7745","authenticated-orcid":false,"given":"Ni","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-98"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102193"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00367-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.041"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0024"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00459-9"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2736"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.05.58"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.012"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040659"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_13_16_1","unstructured":"Global Burden of Disease Collaborative Network \u201cGlobal Burden of Disease Study 2021 (GBD 2021) Results \u201d published2024 https:\/\/vizhub.healthdata.org\/gbd-results\/."},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00429-6"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008601"},{"key":"e_1_2_13_19_1","unstructured":"UK Biobank \u201cGenotyping and Quality Control of UK Biobank A Large\u2010Scale Extensively Phenotyped Prospective Resource \u201d published 2016 https:\/\/biobank.ctsu.ox.ac.uk\/crystal\/crystal\/docs\/genotyping_qc.pdf."},{"key":"e_1_2_13_20_1","unstructured":"J. Marchini \u201cUK Biobank Phasing and Imputation Documentation \u201d published 2015 https:\/\/biobank.ctsu.ox.ac.uk\/crystal\/crystal\/docs\/impute_ukb_v1.pdf."},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6987"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx102"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6835"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7221"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2233"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26105"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3056"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3786"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i262"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40017"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0728-9"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113928"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0377-7"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092375"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2011.03.007"},{"issue":"7","key":"e_1_2_13_41_1","first-page":"B4485","article-title":"On the Aetiology of Hodgkin Lymphoma","volume":"59","author":"Hjalgrim H.","year":"2012","journal-title":"Danish Medical Journal"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.707217"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.015"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2023.PA472"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-27960-2"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.01.001"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2019.1644148"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14147-4"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2016.00056"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0738-x"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24437-5"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157-2518.1000176"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.030"}],"container-title":["Cancer Innovation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cai2.70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cai2.70048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cai2.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:47:33Z","timestamp":1772988453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cai2.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cai2.70048"],"URL":"https:\/\/doi.org\/10.1002\/cai2.70048","archive":["Portico"],"relation":{},"ISSN":["2770-9191","2770-9183"],"issn-type":[{"value":"2770-9191","type":"print"},{"value":"2770-9183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70048"}}