{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:31:42Z","timestamp":1772998302537,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Innovation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sclerosing adenosis (SA) and breast cancer (BC) often exhibit overlapping clinical, imaging, and pathological characteristics, making them difficult to differentiate. SA may also coexist with BC (SA\u2009+\u2009BC), including ductal carcinoma in situ (SA\u2010DCIS) and invasive breast cancer (SA\u2010IBC), which complicates diagnosis even when core\u2010needle biopsy (CNB) suggests SA. This study aimed to develop interpretable AI\u2010based binary and ternary classification models that leverage clinical and imaging features to distinguish SA\u2010only from SA\u2009+\u2009BC and to further differentiate among SA\u2010only, SA\u2010DCIS, and SA\u2010IBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed a cohort of 726 patients with SA (January 2006 to December 2021), comprising 537 SA\u2010only and 189 SA\u2009+\u2009BC cases (90 SA\u2010DCIS, 99 SA\u2010IBC). Multiple machine learning algorithms\u2014logistic regression, support vector machine, decision tree, XGBoost, and random forest\u2014were compared using AUC, accuracy, F1\u2010score, and C\u2010index. Model interpretability was assessed with SHAP to elucidate feature contributions and identify key predictors. Additionally, we incorporated an independent external validation cohort consisting of 113 patients to verify the model's effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>XGBoost consistently outperformed other algorithms in both tasks. Eight features emerged as most informative: age, ultrasound BI\u2010RADS category, maximum and minimum ultrasound diameters, ultrasound margin characteristics, biopsy procedure, mammographic density, and microcalcifications. For binary classification (SA\u2010only vs. SA\u2009+\u2009BC), XGBoost achieved an AUC of 0.925, accuracy of 0.883, and C\u2010index of 0.844. For ternary classification (SA\u2010only, SA\u2010DCIS, SA\u2010IBC), the model achieved an AUC of 0.888, accuracy of 0.811, and C\u2010index of 0.813. Age, ultrasound BI\u2010RADS, and minimum lesion diameter were consistently top predictors. We further proposed a three\u2010tier interpretability framework (global, cohort\u2010level; local, subgroup\u2010level; and individual, case\u2010level) to facilitate clinical translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the substantial risk of coexisting of SA with DCIS or IBC, and the potential for CNB to underestimate disease due to limited sampling, lesions diagnosed as SA on CNB should be evaluated with additional modalities before determining the need for surgical excision. The proposed interpretable AI model enhances discrimination between SA\u2010only and SA with concomitant breast cancer (SA\u2009+\u2009BC), thereby supporting more informed clinical decision\u2010making in breast disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cai2.70049","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:41:07Z","timestamp":1770961267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Binary and Ternary Classification Prediction for Breast Cancer and Breast Sclerosing Adenosis With Interpretable Artificial Intelligence From Clinical and Imaging Features: A Retrospective, Diagnostic Accuracy Cohort Study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8831-7816","authenticated-orcid":false,"given":"Yang","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, 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