{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:01:01Z","timestamp":1776830461164,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2024YFA1107400"],"award-info":[{"award-number":["2024YFA1107400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370142"],"award-info":[{"award-number":["82370142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Innovation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of novel chemotherapy regimens, including brentuximab vedotin (BV) and immune checkpoint inhibitors (ICIs), in children, adolescents, and young adults (CAYA) with Hodgkin lymphoma (HL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on untreated Stage IIB (bulky), III, or IV HL patients (\u2264\u200924 years) who were admitted to Cancer Hospital of the Chinese Academy of Medical Sciences and Beijing Children's Hospital, Capital Medical University, from 2017 to 2024. The cohort compared conventional regimens with BV\u2011based therapies (BV\u2011AVD \u00b1 R). Furthermore, the efficacy and safety of ICIs were evaluated in relapsed\/refractory cHL patients receiving second\u2011line or later therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this comparison between BV and conventional regimens, 182 patients were enrolled. The median follow\u2010up was 38 months. No significant differences were observed in objective response rate (ORR) (96.4%\n                      <jats:italic>vs<\/jats:italic>\n                      95.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.927) or progression\u2010free survival (PFS) rate (92.8%\n                      <jats:italic>vs<\/jats:italic>\n                      95.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.466).However, the incidence of Grade 4 hematologic toxicity was significantly higher with conventional therapy compared to BV\u2010AVD\u00b1R (61.2%\n                      <jats:italic>vs<\/jats:italic>\n                      25.6%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The BV\u2010AVD group alone achieved a significantly higher ORR than the BV \u2010AVD+R group\u00a0(100% vs. 93.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), while there was no significant difference in PFS rate. However, the BV\u2010AVD\u2009+\u2009R group exhibited a significantly higher incidence of Grade 3\u20134 hematologic toxicities (78.8% vs. 20.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). Immune checkpoint inhibitors was well\u2010tolerated with infrequent adverse events, and 18\/19 cases (94.7%) demonstrated treatment efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with stage II Hodgkin lymphoma presenting with bulky disease, as well as those with stage III\u2013IV disease, the BV\u2010AVD regimen is recommended as first\u2010line therapy, given its more favorable toxicity profile.Although ICIs represent a promising therapeutic approach, existing studies are constrained by limited sample sizes. Future research should focus on expanding patient cohorts to refine treatment strategies and ultimately improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cai2.70050","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:38:06Z","timestamp":1773722286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes With Novel Targeted and Immunotherapeutic Regimens in CAYA Hodgkin Lymphoma: A Retrospective Study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6380-2675","authenticated-orcid":false,"given":"Mengqing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Hematology Center, Beijing Children's Hospital Capital Medical University Beijing China"},{"name":"Department of Pediatric, Beijing Jishuitan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengwei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-380X","authenticated-orcid":false,"given":"Jing","family":"Tian","sequence":"additional","affiliation":[{"name":"Hematology Center, Beijing Children's Hospital Capital Medical University Beijing China"},{"name":"Department of Pediatric, Beijing Shijitan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for 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