{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:37:38Z","timestamp":1747147058782,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7222054"],"award-info":[{"award-number":["7222054"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Innovation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report two children with hepatoblastoma (HB) with a history of neonatal necrotizing enterocolitis (NEC). Case 1 was diagnosed with HB at 5 months of age. Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging. After six chemotherapy courses, a partial hepatectomy was performed. Three months after ceasing the chemotherapy, a chest computed tomography scan suggested that distant metastasis of the tumor should be considered, and the lesion was removed. However, 9 months after the operation, alpha\u2010fetoprotein concentrations were increased, and abdominal imaging showed a recurrence of the tumor in situ, resulting in a hepatectomy. Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later. He was diagnosed with HB at 3 years of age. Hepatectomy was performed after five courses of chemotherapy. Chemotherapy was stopped after 10 courses, and alpha\u2010fetoprotein concentrations were normal. At present, both children have survived and are in a healthy condition. Physicians should be aware of the possibility of HB and a history of NEC in children. Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC. The association between these two diseases requires further study.<\/jats:p>","DOI":"10.1002\/cai2.86","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:49:26Z","timestamp":1690253366000},"page":"532-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatoblastoma with neonatal necrotizing enterocolitis: Two case reports"],"prefix":"10.1002","volume":"2","author":[{"given":"Sidou","family":"He","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xisi","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Duan","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binglin","family":"Jian","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Oncology, Key Laboratory of Major Diseases in Children Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Yu","sequence":"additional","affiliation":[{"name":"Imaging Center Department, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libing","family":"Fu","sequence":"additional","affiliation":[{"name":"Pathology Department, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Surgical 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