{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:32:29Z","timestamp":1772735549563,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Innovation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since RNA sequencing has shown that induced pluripotent stem cells (iPSCs) share a common antigen profile with tumor cells, cancer vaccines that focus on iPSCs have made promising progress in recent years. Previously, we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia (T\u2010ALL) have a gene expression profile similar to that of T\u2010ALL cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice with T\u2010ALL were treated with dendritic and T (DC\u2010T) cells loaded with intact and complete antigens from T\u2010ALL\u2010derived iPSCs (T\u2010ALL\u2010iPSCs). We evaluated the safety and antitumor efficiency of autologous tumor\u2010derived iPSC antigens by flow cytometry, cytokine release assay, acute toxicity experiments, long\u2010term toxicity experiments, and other methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results indicate that complete tumor antigens from T\u2010ALL\u2010iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long\u2010term toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T\u2010ALL\u2010iPSC\u2010based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cai2.95","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T11:56:06Z","timestamp":1697716566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the 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