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However, its biological role and underlying mechanism in epithelial ovarian cancer (<jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content>) remain poorly understood. Here, we found that <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> was overexpressed in <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> tissues and cell lines. This overexpression promoted the migration and invasion of <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> cells. Moreover, <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> upregulated the expression of epithelial\u2013mesenchymal transition (<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>) markers, such as <jats:italic>N\u2010cadherin<\/jats:italic> and <jats:italic>Snail<\/jats:italic>, and the Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin\u2010related genes <jats:italic>cyclin\u2010D1<\/jats:italic> and <jats:italic>c\u2010Myc<\/jats:italic>, which were restored via silencing of <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> expression. Furthermore, the inhibitor and activator of the Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin pathway, <jats:styled-content style=\"fixed-case\">XAV<\/jats:styled-content>939 and LiCl, enhanced or decreased, respectively, the effect of <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> on <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>, which further confirmed that <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> promoted <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> progression via activation of Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin signaling. In addition, we found that <jats:italic><jats:styled-content style=\"fixed-case\">EDD<\/jats:styled-content><\/jats:italic>, the human hyperplastic discs gene, was consistent with <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic> expression and also promoted the <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> process and activated Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin signaling. These findings demonstrate that <jats:italic><jats:styled-content style=\"fixed-case\">EDD<\/jats:styled-content><\/jats:italic> might be a downstream factor of <jats:italic><jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3<\/jats:italic>. Taken together, our findings demonstrate the existence of a <jats:styled-content style=\"fixed-case\">GOLPH<\/jats:styled-content>3\u2013Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin\u2013<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> axis in <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> and provide a new therapeutic target to treat <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1040","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T04:52:22Z","timestamp":1490331142000},"page":"834-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["GOLPH3 induces epithelial\u2013mesenchymal transition via Wnt\/<i>\u03b2<\/i>\u2010catenin signaling pathway in epithelial ovarian cancer"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-9163","authenticated-orcid":false,"given":"Jing","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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