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Ubiquinol\u2013cytochrome c reductase hinge protein (UQCRH<\/jats:styled-content>) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH<\/jats:styled-content> abnormalities in hepatocellular carcinoma (HCC<\/jats:styled-content>) and its association with clinical outcomes of patients. UQCRH<\/jats:styled-content> expression in HCC<\/jats:styled-content> was determined via semiquantitative and quantitative real\u2010time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC<\/jats:styled-content> tissues positive for hepatitis B virus surface antigen. UQCRH<\/jats:styled-content> was frequently overexpressed in HCC<\/jats:styled-content> tissues (46.8%, based on 2.1\u2010fold cutoff). UQCRH<\/jats:styled-content> overexpression was observed in HCC<\/jats:styled-content>s with larger tumor size, poorer differentiation, or vascular invasion. Kaplan\u2013Meier analysis revealed significantly shorter overall (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005) and recurrence\u2010free survival (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.027) in patients with tumors overexpressing UQCRH<\/jats:styled-content>. The prognostic impact of UQCRH<\/jats:styled-content> was significant in subgroups of patients divided according to the \u03b1<\/jats:italic>\u2010fetoprotein (AFP<\/jats:styled-content>) level. The patient subgroup with higher AFP<\/jats:styled-content> levels (\u226520\u00a0ng\/mL) exhibited significant differences in 5\u2010year overall (18.5% vs. 67.9%) and recurrence\u2010free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH<\/jats:styled-content> overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP<\/jats:styled-content> levels (<20\u00a0ng\/mL). Multivariate analysis defined UQCRH<\/jats:styled-content> as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH<\/jats:styled-content> overexpression is correlated with poor outcomes of HCC<\/jats:styled-content> patients. Furthermore, in patients grouped as high risk based on elevated AFP<\/jats:styled-content>, lack of UQCRH<\/jats:styled-content> overexpression could be a useful indicator for clinical treatment.<\/jats:p>","DOI":"10.1002\/cam4.1042","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T04:27:56Z","timestamp":1490329676000},"page":"749-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The mitochondrial hinge protein, UQCRH<\/scp>, is a novel prognostic factor for hepatocellular carcinoma"],"prefix":"10.1002","volume":"6","author":[{"given":"Eun\u2010Ran","family":"Park","sequence":"first","affiliation":[{"name":"Division of Radiation Cancer Research Korea Institute of Radiological and Medical Sciences Seoul Korea"},{"name":"Department of Pathology and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Do","family":"Yoo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology Graduate School of Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Yu","sequence":"additional","affiliation":[{"name":"Korean Medicine Clinical Trial Center Kyung Hee University Korean Medicine Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja 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